136553-96-3
136553-96-3
Chemical Structure
JKC 301
- CAS No.: 136553-96-3
- Formula:C32H44N6O7
- Molecular Weight:624.73
InChIKey: KHRTUHCOJNQEQG-IQMXBARESA-N
SMILES: O=C(N[C@@H](C(N(CCC1)[C@]1([H])C2=O)=O)CC(O)=O)[C@H](NC([C@@H](NC([C@@](N2)([H])[C@H](C)CC)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34
Biological Activity: JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].
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JKC 301 | JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking. | |||||||||||||||||||||
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References
- [1]. Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. [Content Brief]
- [2]. Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76. [Content Brief]
