(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist.
For research use only. We do not sell to patients.
- CAS No.: 73168-24-8
- Formula: C52H74N14O12S2
- Molecular Weight:1151.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
![D[LEU4,LYS8]-VP](https://file.medchemexpress.com/product_pic/hy-p1163.gif)
All Vasopressin Receptor Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
9.9 x 10-10 M
Compound: [d(CH2)51.Tyr(Me)2]-AVP
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Displacement of [3H]AVP from human recombinant arginine vasopressin receptor 1a expressed in CHO cells
Displacement of [3H]AVP from human recombinant arginine vasopressin receptor 1a expressed in CHO cells
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[PMID: 26988801] |
| CHO | IC50 |
9.9 x 10-10 M
Compound: [d(CH2)51,Tyr(Me)2]-AVP
|
Displacement of [3H]AVP from human recombinant V1a receptor expressed in CHO cells measured after 60 mins by scintillation counting method
Displacement of [3H]AVP from human recombinant V1a receptor expressed in CHO cells measured after 60 mins by scintillation counting method
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[PMID: 27876250] |
Chemical Information
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CAS No. 73168-24-8
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Molecular Weight 1151.36
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Formula C52H74N14O12S2
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Synonyms
SKF 100273
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Sequence
{Pmp}-{Tyr(Me)}-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bond: Pmp1-Cys6) (Pmp=β-Mercapto-β,β-cyclopentamethylene-propionic acid)
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Sequence Shortening
{Pmp}-{Tyr(Me)}-FQNCPRG-NH2 (Disulfide bond: Pmp1-Cys6) (Pmp=β-Mercapto-β,β-cyclopentamethylene-propionic acid)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Related Classifications
HY-P1162 Related Classifications
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