Ninerafaxstat trihydrochloride
Based on 1 Customer Validation
Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases.
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- Purity : 99.64%
- CAS No.: 2311824-72-1
- 화학식: C22H32Cl3N3O5
- 분자량:524.87
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
3-KAT, fatty acid oxidation[1].
In Vitro
Ninerafaxstat trihydrochloride can reduce myocardial steatosis, improve left ventricular diastolic filling and myocardial energetics[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine model of post-MI HF[2].
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Dosage:30 mg/kg
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Administration:Via osmotic minipump; once daily; 4 weeks
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Result:Increased left ventricular ejection fraction (LVEF) and reduced cardiac fibrosis.
Chemical Information
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CAS No. 2311824-72-1
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Appearance Solid
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분자량 524.87
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화학식 C22H32Cl3N3O5
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Color White to off-white
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SMILES
O=C(C1=CC=CN=C1)OCCN2CCN(CC3=CC=C(OC)C(OC)=C3OC)CC2.[H]Cl.[H]Cl.[H]Cl
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Synonyms
MB-1018972 trihydrochloride; IMB-101 trihydrochloride
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 41.67 mg/mL (79.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9052 mL | 9.5262 mL | 19.0523 mL | 47.6308 mL |
| 5 mM | 0.3810 mL | 1.9052 mL | 3.8105 mL | 9.5262 mL | |
| 10 mM | 0.1905 mL | 0.9526 mL | 1.9052 mL | 4.7631 mL | |
| 15 mM | 0.1270 mL | 0.6351 mL | 1.2702 mL | 3.1754 mL | |
| 20 mM | 0.0953 mL | 0.4763 mL | 0.9526 mL | 2.3815 mL | |
| 25 mM | 0.0762 mL | 0.3810 mL | 0.7621 mL | 1.9052 mL | |
| 30 mM | 0.0635 mL | 0.3175 mL | 0.6351 mL | 1.5877 mL | |
| 40 mM | 0.0476 mL | 0.2382 mL | 0.4763 mL | 1.1908 mL | |
| 50 mM | 0.0381 mL | 0.1905 mL | 0.3810 mL | 0.9526 mL | |
| 60 mM | 0.0318 mL | 0.1588 mL | 0.3175 mL | 0.7938 mL |
Ninerafaxstat trihydrochloride Related Classifications
HY-139577A Related Classifications
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