Phospholipase A2  (Synonyms: PLA2)

Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research^[1][2][3][4].

Phospholipase A2-modified apoB-100 lipoproteins, which are more susceptible to further enzymatic and nonenzymatic modifications, induce accumulation of intracellular lipids in macrophages and bind strongly to extracellular matrix proteoglycans^[2].
Phospholipase A2 can induce aggregation and fusion of the matrix-bound lipoproteins and so further increase their binding strength to the matrix proteoglycans^[2].
Phospholipase A2 can modify the circulating lipoproteins and so induce formation of small dense LDL particles, which are associated with increased risk for cardiovascular disease^[2].
Phospholipase A2 injures lymphatic endothelial cells leading to progression of secondary lymphoedema^[3].
Phospholipases A2 can be used for the synthesis of prostaglandins, leukotrienes, platelet-activating factors, and other bioactive lipids^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-84-7

Solid

White to off-white

[Phospholipase A2]

3.1.1.4

≥10 U/mL

One unit is defined as the amount of enzyme that will hydrolyze 1.0 μmole of soybean L-αphosphatidylcholine to L-α-lysophosphatidylcholine and afatty acid per min at pH 8.0 at 37°C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Murakami M, Kudo I. Phospholipase A2. J Biochem. 2002 Mar;131(3):285-92.  [Content Brief]

  [2]. Hurt-Camejo E, et al. Phospholipase A(2) in vascular disease. Circ Res. 2001 Aug 17;89(4):298-304.  [Content Brief]

  [3]. Zhao Z, et al. Phospholipase A2 (PLA2) injured lymphatic endothelial cells leading to progression of secondary lymphoedema. Biotechnol Genet Eng Rev. 2024 Nov;40(3):1511-1534.  [Content Brief]

  [4]. Burch RM. Phospholipase A2 activity. Methods Mol Biol. 1995;41:279-84. doi: 10.1385/0-89603-298-1:279. PMID: 7655564.  [Content Brief]