Phospholipase A2
Based on 1 publication(s) in Google Scholar
Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research.
For research use only. We do not sell to patients.
- CAS No.: 9001-84-7
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Phospholipase A2
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Biological Activity
Description
In Vitro
Phospholipase A2-modified apoB-100 lipoproteins, which are more susceptible to further enzymatic and nonenzymatic modifications, induce accumulation of intracellular lipids in macrophages and bind strongly to extracellular matrix proteoglycans[2].
Phospholipase A2 can induce aggregation and fusion of the matrix-bound lipoproteins and so further increase their binding strength to the matrix proteoglycans[2].
Phospholipase A2 can modify the circulating lipoproteins and so induce formation of small dense LDL particles, which are associated with increased risk for cardiovascular disease[2].
Phospholipase A2 injures lymphatic endothelial cells leading to progression of secondary lymphoedema[3].
Phospholipases A2 can be used for the synthesis of prostaglandins, leukotrienes, platelet-activating factors, and other bioactive lipids[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
3.1.1.4
Enzyme Activity
≥10 U/mL
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 1.0 μmole of soybean L-αphosphatidylcholine to L-α-lysophosphatidylcholine and afatty acid per min at pH 8.0 at 37°C
Chemical Information
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CAS No. 9001-84-7
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Appearance Solid
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Color White to off-white
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SMILES
[Phospholipase A2]
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Synonyms
PLA2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
H2O : ≥ 25 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Murakami M, Kudo I. Phospholipase A2. J Biochem. 2002 Mar;131(3):285-92. [Content Brief]
[2]. Hurt-Camejo E, et al. Phospholipase A(2) in vascular disease. Circ Res. 2001 Aug 17;89(4):298-304. [Content Brief]
[3]. Zhao Z, et al. Phospholipase A2 (PLA2) injured lymphatic endothelial cells leading to progression of secondary lymphoedema. Biotechnol Genet Eng Rev. 2024 Nov;40(3):1511-1534. [Content Brief]
[4]. Burch RM. Phospholipase A2 activity. Methods Mol Biol. 1995;41:279-84. doi: 10.1385/0-89603-298-1:279. PMID: 7655564. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phospholipase A2 Related Classifications
HY-P3029 Related Classifications
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