Phospholipase A2, Crotalus adamanteus Venom  (Synonyms: PLA2, Crotalus adamanteus Venom)

Phospholipase A2 (PLA2), Crotalus adamanteus Venom is a membrane phospholipid-targeting enzyme. Phospholipase A2, Crotalus adamanteus catalyzes cleavage of the sn-2-acyl bond of membrane phospholipids, producing lysophospholipids and free fatty acids. Phospholipase A2, Crotalus adamanteus Venom can be used for biochemical research^[1][2][3][4].

Phospholipase A2, Crotalus adamanteus Venom is a stable, calcium²⁺-dependent enzyme with preferential activity toward aggregated phospholipid substrates^[1].
Phospholipase A2, Crotalus adamanteus Venom is inhibited by a broad range of compounds acting through multiple mechanisms, including interface disruption, calcium modulation, non-specific binding, and covalent enzyme modification^[1].
Phospholipase A2, Crotalus adamanteus Venom activity is inhibited by kaempferol, quercetin, myricetin, and vitamin E, while flavanones with a reduced C-ring 2-3 double bond show diminished inhibitory activity against this enzyme^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-84-7

Solid

White to off-white

[Phospholipase A2, Crotalus adamanteus Venom]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chang J, et al. Phospholipase A2: function and pharmacological regulation. Biochem Pharmacol. 1987 Aug 1;36(15):2429-36.  [Content Brief]

  [2]. Grass DS, et al. Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate. J Clin Invest. 1996 May 15;97(10):2233-41.  [Content Brief]

  [3]. Lin G, et al. Phospholipase A2 Catalyses in Organic Media. Tetrahedron Letters 1993, 34 (12), 1959–1962.

  [4]. Nanda BL, Nataraju A, Rajesh R, et al.. PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule. Current topics in medicinal chemistry. 2007;7(8):765-77.  [Content Brief]