MIF-1
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).
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- CAS 番号: 2002-44-0
- 分子式: C13H24N4O3
- 分子量:284.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Dopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
2.6 μM
Compound: 1a
|
In vitro cytotoxic activity against CCRF-CEM human lymphoblastoid cells in culture.
In vitro cytotoxic activity against CCRF-CEM human lymphoblastoid cells in culture.
|
10.1016/0960-894X(96)00451-9 |
MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; once, for 1 hour
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Result:Decreased the analgesic effect. Increased the pain threshold for at least 1 h.
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Animal Model:Sprague-Dawley rats[3]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; daily, for 8 weeks
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Result:Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.
化学情報
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CAS 番号 2002-44-0
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分子量 284.35
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分子式 C13H24N4O3
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別名
Pro-Leu-Gly-NH2; Melanostatin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Bocheva A, et, al. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26(9):673-7. [Content Brief]
[2]. Valentijn JA, et, al. Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. J Physiol. 1994 Mar 1;475(2):185-95. [Content Brief]
[3]. Saleh MI, et, al. MIF-1 attenuates spiroperidol alteration of striatal dopamine D2 receptor ontogeny. Peptides. 1989 Jan-Feb;10(1):35-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MIF-1 関連分類
HY-107663 関連分類
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