1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. PPAR
    Mitochondrial Metabolism
  3. (S)-Coriolic acid

(S)-Coriolic acid (Synonyms: 13(S)-HODE)

Cat. No.: HY-113884B
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(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.

For research use only. We do not sell to patients.

(S)-Coriolic acid Chemical Structure

(S)-Coriolic acid Chemical Structure

CAS No. : 29623-28-7

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Description

(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].

In Vitro

(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium[2].
(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6-8 weeks)[2]
Dosage: 0-0.6 mg per mouse
Administration: Intranasally once a day for 3 consecutive days
Result: BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.
Molecular Weight

296.44

Formula

C₁₈H₃₂O₃

CAS No.
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(S)-Coriolic acid
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HY-113884B
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