29623-28-7
Chemical Structure
(S)-Coriolic acid
Synonym(s): 13(S)-HODE
- CAS No.: 29623-28-7
- Formula:C18H32O3
- Molecular Weight:296.44
IUPAC Name: (S,9Z,11E)-13-hydroxyoctadeca-9,11-dienoic acid
InChIKey: HNICUWMFWZBIFP-IRQZEAMPSA-N
SMILES: CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
Biological Activity: (S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Coriolic acid | 99.0% | (S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury. | ||||||||||||||||||||
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13(S)-HODE-d4 | 13(S)-HODE-d4 is the deuterium labeled 13(S)-HODE. | |||||||||||||||||||||
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- [1]. Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349. [Content Brief]
- [2]. Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131(3):604-612. [Content Brief]
- [3]. Yuan H, et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax. 2010;65(4):321-326. [Content Brief]
Keywords
