1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. p-Toluic acid

p-Toluic acid  (Synonyms: 4-Methylbenzoic acid)

Cat. No.: HY-76547 Purity: 99.69%
COA Handling Instructions

p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis.

For research use only. We do not sell to patients.

p-Toluic acid Chemical Structure

p-Toluic acid Chemical Structure

CAS No. : 99-94-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

In reproductive/developmental studies, p-Toluic acid (1 g/kg; po, once daily for 28 days) decreases epididymal weight and increases the incidence of oligozoospermia/azoospermia in the cauda epididymis in rats[2].
p-Toluic acid doesn't show any adverse effects on the animal's reproductive organs at doses of 0, 100, 300 or 1,000 mg/kg and doesn't affect the estrous cycle or mating performance. The NOEL for p-Toluic acid in male and female rats are considered to be 300 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female rats[2]
Dosage: 0, 100, 300, 1,000 mg/kg
Administration: po; once daily for 28 days
Result: Resulted temporal salivation, a slight increase in food consumption and a moderate increase in blood aspartate aminotransferase (AST) activity under 1000 mg/kg dose.
NOEL is considered to be 300 mg/kg for male and female rats.
Molecular Weight

136.15

Formula

C8H8O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(C=C1)=CC=C1C

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (734.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3448 mL 36.7242 mL 73.4484 mL
5 mM 1.4690 mL 7.3448 mL 14.6897 mL
10 mM 0.7345 mL 3.6724 mL 7.3448 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.69%

References
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p-Toluic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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p-Toluic acid
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