1. Anti-infection
  2. Bacterial
    Antibiotic
  3. AFN-1252

AFN-1252 (Synonyms: API-1252; Debio 1452)

Cat. No.: HY-16911 Purity: 99.13%
Handling Instructions

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

For research use only. We do not sell to patients.

AFN-1252 Chemical Structure

AFN-1252 Chemical Structure

CAS No. : 620175-39-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. IC50 value: Target: Antibiotic agent AFN-1252 was inactive (MIC90, >4 μg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.

Molecular Weight

375.42

Formula

C₂₂H₂₁N₃O₃

CAS No.

620175-39-5

SMILES

O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C(C=C3CC4)=CNC3=NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.8 mg/mL (15.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6637 mL 13.3184 mL 26.6368 mL
5 mM 0.5327 mL 2.6637 mL 5.3274 mL
10 mM 0.2664 mL 1.3318 mL 2.6637 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AFN-1252API-1252 Debio 1452AFN1252AFN 1252API1252API 1252Debio1452Debio 1452Debio-1452BacterialAntibioticInhibitorinhibitorinhibit

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AFN-1252
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HY-16911
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