2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Carnitine hydrochloride

L-Carnitine hydrochloride  (Synonyms: (R)-Carnitine hydrochloride; Levocarnitine hydrochloride)

Cat. No.: HY-B2246 Purity: ≥98.0%
COA Handling Instructions

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

For research use only. We do not sell to patients.

L-Carnitine hydrochloride Chemical Structure

L-Carnitine hydrochloride Chemical Structure

CAS No. : 6645-46-1

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Based on 8 publication(s) in Google Scholar

Other Forms of L-Carnitine hydrochloride:

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Description

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vivo

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-weeks-old and weighed 28-30g BALB/c mice[2]
Dosage: 125, 250 mg/kg
Administration: i.p.
Result: SaO2 increased significantly at 250 mg/kg and decreased urinaryLTE4 excretion.
Clinical Trial
Molecular Weight

197.66

Appearance

Solid

Formula

C7H16ClNO3
CAS No.
SMILES

C[N+](C)(C)C[[email protected]](O)CC(O)=O.[Cl-]
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1264.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0592 mL 25.2960 mL 50.5919 mL
5 mM 1.0118 mL 5.0592 mL 10.1184 mL
10 mM 0.5059 mL 2.5296 mL 5.0592 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (252.96 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (148 KB) MS (66 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

L-Carnitine6645-46-1(R)-CarnitineLevocarnitineEndogenous Metabolitepolarzwitterionco-factorlong-chainfattyacidsmitochondrialmatrixantioxidant metabolismInhibitorinhibitorinhibit

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