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  3. Liothyronine sodium

Liothyronine sodium (Synonyms: Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium)

Cat. No.: HY-A0070 Purity: 99.17%
Handling Instructions

Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

For research use only. We do not sell to patients.

Liothyronine sodium Chemical Structure

Liothyronine sodium Chemical Structure

CAS No. : 55-06-1

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 144 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Liothyronine sodium:

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Publications Citing Use of MCE Liothyronine sodium

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  • Customer Review

Description

Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

IC50 & Target

TRβ1[1][2]

In Vitro

Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].

Clinical Trial
Molecular Weight

672.96

Formula

C₁₅H₁₁I₃NNaO₄

CAS No.

55-06-1

SMILES

N[[email protected]@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 42 mg/mL (62.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4860 mL 7.4299 mL 14.8597 mL
5 mM 0.2972 mL 1.4860 mL 2.9719 mL
10 mM 0.1486 mL 0.7430 mL 1.4860 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine (T3) on the growth of cells, cells are plated at a density of 3 × 104 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.17%

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Keywords:

LiothyronineTriiodothyronine3,3',5-Triiodo-L-thyronineT3T 3T-3Thyroid Hormone ReceptorTHRInhibitorinhibitorinhibit

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Liothyronine sodium
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HY-A0070
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