1. Stem Cell/Wnt
  2. Smo
    Hedgehog
  3. SANT-1

SANT-1 

Cat. No.: HY-100224 Purity: 99.85%
Handling Instructions

SANT-1, un antagoniste de puissant de Smo, inhibe la signalisation Hedgehog. SANT-1 montre des IC50 de 20 nM et 30 nM dans les tests Shh-LIGHT2 et SmoA1-LIGHT2, respectivement.

SANT-1, ein potenter Smo-Antagonist, hemmt die Hedgehog-Signalübertragung. SANT-1 zeigt IC50s von 20 nM und 30 nM im Shh-LIGHT2- bzw. SmoA1-LIGHT2-Assay.

SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.

For research use only. We do not sell to patients.

SANT-1 Chemical Structure

SANT-1 Chemical Structure

CAS No. : 304909-07-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].

IC50 & Target

IC50: 20 nM (Shh signaling), 30 nM (SmoA1)[1]

In Vitro

SANT-1 is a potent Smo antagonist, binds directly to Smo, and inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cells, respectively[1].
SANT-1 (1 μM, for 24 or 48 hours) decreases the proliferation of medulloblastoma cells[2].

Cell Viability Assay[2]

Cell Line: Medulloblastoma cells
Concentration: 1 μM
Incubation Time: 24 hours or 48 hours
Result: Inhibited cellular proliferation in primary tumorspheres.
Molecular Weight

373.49

Formula

C₂₃H₂₇N₅

CAS No.

304909-07-7

SMILES

CC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (167.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6774 mL 13.3872 mL 26.7745 mL
5 mM 0.5355 mL 2.6774 mL 5.3549 mL
10 mM 0.2677 mL 1.3387 mL 2.6774 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SANT-1SANT1SANT 1SmoHedgehogSmoothenedInhibitorinhibitorinhibit

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SANT-1
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HY-100224
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