2. Disease Areas
  3. Cancer Neurological, Eye or Ear Disease
  4. Glioma CNS Neoplasm
  5. Medulloblastoma

Medulloblastoma

Medulloblastoma is the most common malignant brain tumor in children, with peak incidence between 3–4 and 8–9 years of age, accounting for 16% of pediatric brain tumors and 40% of cerebellar tumors in children, while occurring in 10–15% of cases in infancy. In adults, it is rare, representing less than 1% of central nervous system tumors, with highest incidence in the 20–34 age group. It may be associated with Gorlin and Turcot syndromes, arises from cerebellar neural stem cell precursors, and presents with symptoms such as headaches, nausea, vomiting, and ataxia, often spreading through cerebrospinal fluid. Treatment involves surgery, chemotherapy, and radiation. Histological subtypes include large-cell/anaplastic, desmoplastic/nodular, and medulloblastoma with extensive nodularity. Molecular classification divides it into WNT, SHH, Group 3, and Group 4 subgroups, each with distinct genetic profiles and clinical behavior.

Medulloblastoma (6):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-D1668
    Biotin-11-dCTP 99.1%
    Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase.
    Biotin-11-dCTP
  • HY-179078
    CT-179 1996636-69-1 99.61%
    CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma.
    CT-179
  • HY-P992055
    Anti-ITGB1 Antibody
    Anti-ITGB1 Antibody (AIIB2) is a monoclonal antibody targeting integrin-β1 (integrin-β1). Anti-ITGB1 Antibody blocks the binding of the ITGB1 subunit to type I collagen ligands, and abrogates the adhesion of cancer cells to type I collagen-coated surfaces. Anti-ITGB1 Antibody inhibits the proliferation and induces apoptosis of human osteosarcoma cells by activating caspase-3 and regulating apoptosis-related proteins. Anti-ITGB1 Antibody is applicable to research related to osteosarcoma and medulloblastoma.
    Anti-ITGB1 Antibody
  • HY-170900
    SJ44236
    SJ44236 is a BET PROTAC degrader with activity against BRD2, BRD3 and BRD4 (DC50 = 127 pM). SJ44236 induces ubiquitination and proteasomal degradation by forming a ternary complex with BET proteins and CRBN-DDB1. SJ44236 downregulates c-Myc, upregulates p53 and reduces cancer cell viability. SJ44236 can be used for the research of leukemia and medulloblastoma.
    SJ44236
  • HY-182433
    CJM061 1847445-87-7
    CJM061 is a WEE1 kinase inhibitor with a target IC50 of 2.8 nM. CJM061 acts as a sensitizer and exhibits synergistic effects with Cisplatin (HY-17394) in medulloblastoma cells. CJM061 can be used for the research of medulloblastoma.
    CJM061
  • HY-164401A
    QBS10072S dihydrochloride 1802735-31-4
    QBS10072S dihydrochloride is a LAT1-selective substrate with blood-brain barrier permeability that inhibits tumor growth. QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces interstrand DNA cross-linking and cell apoptosis, and reduces leptomeningeal dissemination. QBS10072S dihydrochloride can be used in studies related to glioblastoma multiforme, diffuse intrinsic pontine glioma, triple-negative breast cancer brain metastases, and aggressive T-cell lymphoma.
    QBS10072S dihydrochloride