Anti-ITGB1 Antibody
Based on 1 Customer Validation
Anti-ITGB1 Antibody (AIIB2) is a monoclonal antibody targeting integrin-β1 (integrin-β1). Anti-ITGB1 Antibody blocks the binding of the ITGB1 subunit to type I collagen ligands, and abrogates the adhesion of cancer cells to type I collagen-coated surfaces. Anti-ITGB1 Antibody inhibits the proliferation and induces apoptosis of human osteosarcoma cells by activating caspase-3 and regulating apoptosis-related proteins. Anti-ITGB1 Antibody is applicable to research related to osteosarcoma and medulloblastoma.
For research use only. We do not sell to patients.
- Purity : 96.16%
- Molecular Weight:146.18 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
Caspase-3 |
In Vitro
Anti-ITGB1 Antibody (10-40 μM; 48 h) inhibits proliferation and induces apoptosis in human osteosarcoma MG63 cells by activating caspase-3 and regulating apoptosis-related proteins, while exerting no significant effect on normal osteoblast hFOB1.19 cells[1].
Anti-ITGB1 Antibody (1 h) completely abrogates the adhesion of D283 medulloblastoma cells to type I collagen matrix in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hFOB1.19 and MG-63 cells
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Concentration:0, 10, 20, 40 μM
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Incubation Time:48 h
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Result:Suppressed the cell proliferation of MG63 cells, without significant inhibitory effect in normal blast cell line, hFOB1.1.
Gene ID
Accession
Target
Integrin b1/ITGB1/CD29
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 146.18 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
AIIB2
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Li R, et al. NF-κB signaling and integrin-β1 inhibition attenuates osteosarcoma metastasis via increased cell apoptosis. Int J Biol Macromol. 2019;123:1035-1043. [Content Brief]
[2]. Liang Y, et al. Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol. 2008;86(2):133-141. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-ITGB1 Antibody Related Classifications
HY-P992055 Related Classifications
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