ITGB1 - integrin subunit beta 1 Gene

Also Known as CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3688

About ITGB1

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,900,318-32,958,230 (from NCBI)

This gene has 36 transcripts (splice variants), 304 orthologues and 8 paralogues. Ubiquitous expression in fat (RPKM 292.8), gall bladder (RPKM 214.5) and 25 other tissues.

Summary

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ITGB1 Products (3)

mRNA	Protein	Name
NM_002211.4	NP_002202.2	integrin beta-1 isoform 1A precursor
NM_033668.2	NP_391988.1	integrin beta-1 isoform 1D precursor
NM_133376.3	NP_596867.1	integrin beta-1 isoform 1A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to C-X3-C chemokine binding	IDA IDA: Inferred from direct assay	23125415	GOA
enables actin binding	IDA IDA: Inferred from direct assay	16803572	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	33962943	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables collagen binding involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24823363	GOA
enables fibronectin binding	IDA IDA: Inferred from direct assay	26763945	GOA
enables fibronectin binding	IPI IPI: Inferred from physical interaction	11792823	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	33962943	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	10455171	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1542691	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	10455171	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	26763945	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25336636	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD40 signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	29763414	GOA
acts upstream of or within calcium-independent cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	19651211	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	19703720	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12807887	GOA
involved in cell-cell adhesion mediated by integrin	IEP IEP: Inferred from expression pattern	17704059	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9679049	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	30992345	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24823363	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	1715889	GOA
involved in leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	15006356	GOA
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	35802072	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	25911094	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24044949	GOA
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	19364818	GOA
involved in positive regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	24044949	GOA
involved in positive regulation of fibroblast migration	IDA IDA: Inferred from direct assay	26763945	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	24044949	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	10455171	GOA
involved in positive regulation of vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	24044949	GOA
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	26763945	GOA
involved in regulation of collagen catabolic process	IDA IDA: Inferred from direct assay	10455171	GOA
NOT involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24036928	GOA
NOT involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	1715889	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16803572	GOA
located in filopodium	IDA IDA: Inferred from direct assay	16803572	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	14970227	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	12417594	GOA
part of integrin alpha1-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha10-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha10-beta1 complex	IPI IPI: Inferred from physical interaction	9685391	GOA
part of integrin alpha11-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha2-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha2-beta1 complex	IPI IPI: Inferred from physical interaction	14681217	GOA
part of integrin alpha3-beta1 complex	IDA IDA: Inferred from direct assay	24220332	GOA
part of integrin alpha4-beta1 complex	IPI IPI: Inferred from physical interaction	1542691	GOA
part of integrin alpha5-beta1 complex	IDA IDA: Inferred from direct assay	31331973	GOA
part of integrin alpha5-beta1 complex	IPI IPI: Inferred from physical interaction	22451694	GOA
part of integrin alpha6-beta1 complex	IPI IPI: Inferred from physical interaction	2649503	GOA
part of integrin alpha9-beta1 complex	IPI IPI: Inferred from physical interaction	25748048	GOA
part of integrin alphav-beta1 complex	IPI IPI: Inferred from physical interaction	25398877	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	14559243	GOA
located in neuromuscular junction	IDA IDA: Inferred from direct assay	9415431	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20183869	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12869515	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	14970227	GOA
located in sarcolemma	IDA IDA: Inferred from direct assay	9415431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB1 Protein Structure

Integrin_beta

EGF_2

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
798 a.a.

Protein Preferred Names	Protein Names
integrin beta-1	glycoprotein IIa

ITGB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	ITGB1	P05556	Tln1	Mus musculus	P26039	FRET	21947080
Intra	ITGB1	P05556	ITGA5	Homo sapiens	P08648	Anti Bait CoIP	12724312
Intra	ITGB1	P05556	ITGA5	Homo sapiens	P08648	Pull Down	22178926
Intra	ITGB1	P05556	CX3CL1	Homo sapiens	P78423	Pull Down	24789099
Intra	ITGB1	P05556	CX3CL1	Homo sapiens	P78423	ELISA	24789099
Intra	ITGB1	P05556	CSF2RB	Homo sapiens	P32927	Anti Bait CoIP	20802515
Intra	ITGB1	P05556	CSF2RB	Homo sapiens	P32927	Pull Down	20802515
Cross	ITGB1	P05556	Rab21	Mus musculus	P35282	Anti Bait CoIP	16754960
Intra	ITGB1	P05556	ITGA6	Homo sapiens	P23229	Immunodepletion CoIP	2649503
Intra	ITGB1	P05556	TLN1	Homo sapiens	Q9Y490	Solid Phase Assay	11279249
Intra	ITGB1	P05556	ENG	Homo sapiens	P17813	Anti Tag CoIP	22940691
Intra	ITGB1	P05556	ANGPTL4	Homo sapiens	Q9BY76	SPR	21397862
Intra	ITGB1	P05556	FLNA	Homo sapiens	P21333	Pull Down	17690686
Intra	ITGB1	P05556	FLNA	Homo sapiens	P21333	Anti Bait CoIP	18177638
Intra	ITGB1	P05556	IGF1R	Homo sapiens	P08069	Anti Bait CoIP	15289498
Intra	ITGB1	P05556	ITGA2	Homo sapiens	P17301	Lex-A Dimerization	14681217
Intra	ITGB1	P05556	ITGA4	Homo sapiens	P13612	Lex-A Dimerization	14681217
Intra	ITGB1	P05556	ITGA4	Homo sapiens	P13612	Anti Bait CoIP	20159608
Intra	ITGB1	P05556	ACE2	Homo sapiens	Q9BYF1	Crosslink	22523556
Intra	ITGB1	P05556	ACE2	Homo sapiens	Q9BYF1	IF	22523556
Intra	ITGB1	P05556	ACE2	Homo sapiens	Q9BYF1	Anti Bait CoIP	22523556
Intra	ITGB1	P05556	ADAM17	Homo sapiens	P78536	Anti Bait CoIP	30455686
Intra	ITGB1	P05556	LYN	Homo sapiens	P07948	Anti Bait CoIP	20159608
Intra	ITGB1	P05556	LYN	Homo sapiens	P07948	Confocal	20159608
Intra	ITGB1	P05556	PTPN1	Homo sapiens	P18031	Phosphatase Assay	21806020

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70257	Integrin beta-1/CD29 Protein, Human (HEK293, His)	P05556-1 (Q21-D728)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73869	Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His)	P53708 (F39-L1012)&P05556-1 (Q21-D728)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P73871	Integrin alpha 6 beta 1 Protein, Human (HEK293, Flag-His)	P23229-3 (F24-S1011)&P05556-1 (Q21-D728)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73872	Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His)	P08648 (F42-Y995) & P05556-1 (Q21-D728)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77718	Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi)	P08648 (F42-Y995)&P05556-1 (Q21-D728)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

ITGB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80418	Integrin beta 1 Antibody (YA337)	WB, IHC-P	Human, Mouse
HY-P86388	Integrin beta 1 Antibody (YA6080)	WB, IHC-P, ELISA, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Mucormycosis	Zygomycosis Disseminated Mucormycosis Absidia Infection Absidia Mucoromycosis Cunninghamella Infection Cunninghamella Mucoromycosis Infection By Absidia Spp Infection By Rhizopus Spp Mucor Infection Mucor Mucoromycosis Infection By Mucor Spp Rhizopus Infection Rhizopus Mucoromycosis Infection By Cunninghamella Spp Phycomycosis Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Hydrocele	Testicular Hydrocele
Bullous Keratopathy	Bk - [Bullous Keratopathy]
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Erythroleukemia
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Synovitis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Psoriasis
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Cervical Non-Keratinizing Squamous Cell Carcinoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990643	OS-2966	Inhibitor	99.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06963	ITGB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16668	Itgb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-E70297	N-Acetylglucosaminyltransferase IVa		/	Unkown
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23103	Itgb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992055	Anti-ITGB1 Antibody		96.16%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ITGB1	VGNC	VGNC:30324
Rattus norvegicus	ITGB1	RGD	RGD:2927
Canis familiaris	ITGB1	VGNC	VGNC:42136
Mus musculus	ITGB1	MGD	MGI:96610
Felis catus	ITGB1	VGNC	VGNC:84040
Macaca mulatta	ITGB1	VGNC	VGNC:73784
Others	ITGB1	NCBI