TLN1 - talin 1 Gene

Also Known as TLN; ILWEQ; talin-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7094

About TLN1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,696,948-35,732,195 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues.

Summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to Other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

TLN1 Products (1)

mRNA Protein Name
NM_006289.4 NP_006280.3 talin-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables LIM domain binding IPI
IPI: Inferred from physical interaction
10320340 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
12473654 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11279249 GOA
enables vinculin binding IPI
IPI: Inferred from physical interaction
15070891 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IMP
IMP: Inferred from mutant phenotype
26923917 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
15070891 GOA
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
26923917 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLN1 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (90 - 199)

FERM_M

FERM_M: FERM central domain (204 - 313)

IRS

IRS: PTB domain (IRS-1 type) (324 - 397)

Talin_middle

Talin_middle: Talin, middle domain (491 - 652)

VBS

VBS: Vinculin Binding Site (1234 - 1350)

VBS

VBS: Vinculin Binding Site (1849 - 1973)

I_LWEQ

I_LWEQ: I/LWEQ domain (2385 - 2531)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2541 a.a.
Protein Preferred Names Protein Names

talin-1

TLN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLN1 Q9Y490 RET Homo sapiens P07949
Phage Display
39009827
Intra
TLN1 Q9Y490 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
TLN1 Q9Y490 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
TLN1 Q9Y490 ITGB3 Homo sapiens P05106
ELISA
16546176
Intra
TLN1 Q9Y490 ITGB1 Homo sapiens P05556
Solid Phase Assay
11279249
Intra
TLN1 Q9Y490 PIP5K1C Homo sapiens O60331
FPS
35044719
Cross: Cross-species interaction Intra: Intraspecies interaction

TLN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87123 Talin 1 Antibody (YA6816) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Capillary Leak Syndrome

  • Systemic Capillary Leak Syndrome

  • Clarkson Disease

  • Capillary Leak Syndrome With Monoclonal Gammopathy

  • Scls

  • Periodic Systemic Capillary Leak Syndrome

  • Capillary Hyperpermeability Syndrome

  • Idiopathic Capillary Leak Syndrome
Adenomyosis

  • Endometriosis Of Uterus

  • Endometriosis Interna

  • Endometriosis Of Myometrium

  • Endometriosis, Myometrium

  • Uterine Adenomyosis

  • Adenomyosis Uteri

  • Internal Endometriosis
Leukocyte Adhesion Deficiency, Type I

  • Leukocyte Adhesion Deficiency

  • Leukocyte Adhesion Deficiency 1

  • LAD1

  • Lad

  • Lymphocyte Function-Associated Antigen 1 Immunodeficiency

  • Leukocyte Adhesion Deficiency Type I

  • Leukocyte Adhesion Deficiency Type 1

  • Linear Iga Bullous Dermatosis

  • Linear Iga Dermatosis

  • Leukocyte-Adhesion Deficiency Syndrome

  • Lfa1 Immunodeficiency

  • Congenital Leukocyte Adherence Deficiency

  • Lad-I

  • Linear Iga Disease

  • Leukocyte Adhesion Deficiency Syndrome

  • Lad 1

  • Lfa 1 Immunodeficiency

  • Linear Immunoglobulin A Dermatosis

  • Leucocyte Adhesion Deficiency Type 1

  • Leukocyte Adhesion Molecule Deficiency Type 1
Leukocyte Adhesion Deficiency, Type Iii

  • Leukocyte Adhesion Deficiency 3

  • LAD3

  • Leukocyte Adhesion Deficiency 1 Variant

  • Lad1v

  • Integrin Activation Deficiency Disease

  • Iadd

  • Leukocyte Adhesion Deficiency Type Iii

  • Lad1 Variant

  • Lad-1 Variant

  • Lad-Iii

  • Leukocyte Adhesion Deficiency-1 Variant

  • Leukocyte Adhesion Deficiency Type 1
Focal Segmental Glomerulosclerosis

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Focal Glomerulosclerosis

  • Fsgs

  • Segmental Glomerulosclerosis

  • Glomerulosclerosis, Focal Segmental

  • Fgs

  • Focal Glomerular Sclerosis

  • Familial Idiopathic Nephrotic Syndrome

  • Focal Sclerosis With Hyalinosis

  • Glomerulosclerosis, Focal

  • Glomerulosclerosis Focal

  • Glomerulosclerosis, Segmental, Focal

  • Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14574 TLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22345 Tln1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TLN1 VGNC VGNC:35897
Canis familiaris TLN1 VGNC VGNC:47401
Felis catus TLN1 VGNC VGNC:66215
Mus musculus TLN1 MGD MGI:1099832
Macaca mulatta TLN1 VGNC VGNC:78371
Rattus norvegicus TLN1 RGD RGD:1306247
Others TLN1 NCBI