ITGA2 - integrin subunit alpha 2 Gene

Also Known as BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3673

About ITGA2

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,989,352-53,094,779 (from NCBI)

This gene has 6 transcripts (splice variants), 240 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 8.4), adrenal (RPKM 7.9) and 21 other tissues.

Summary

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and Other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

ITGA2 Products (1)

mRNA	Protein	Name
NM_002203.4	NP_002194.2	integrin alpha-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IMP IMP: Inferred from mutant phenotype	11518510	GOA
enables collagen binding involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24823363	GOA
enables collagen receptor activity	IMP IMP: Inferred from mutant phenotype	11518510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7639691	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25336636	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in collagen-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24823363	GOA
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in substrate-dependent cell migration	IMP IMP: Inferred from mutant phenotype	11518510	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19933311	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	11518510	GOA
part of integrin alpha2-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha2-beta1 complex	IPI IPI: Inferred from physical interaction	14681217	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21310825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA2 Protein Structure

VWA

FG-GAP

Integrin_alpha2

0
200
400
600
800
1000
1181 a.a.

Protein Preferred Names	Protein Names
integrin alpha-2	CD49 antigen-like family member B

ITGA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGA2	P17301	KDR	Homo sapiens	P35968	Anti Bait CoIP	21596751
Cross	ITGA2	P17301	Rab21	Mus musculus	P35282	Density Sedimentation	16754960
Cross	ITGA2	P17301	Rab21	Mus musculus	P35282	Y2H	16754960
Cross	ITGA2	P17301	Rab21	Mus musculus	P35282	Anti Tag CoIP	16754960
Cross	ITGA2	P17301	Rab21	Mus musculus	P35282	Anti Bait CoIP	16754960
Intra	ITGA2	P17301	SHARPIN	Homo sapiens	Q9H0F6	Pull Down	21947080
Intra	ITGA2	P17301	SHARPIN	Homo sapiens	Q9H0F6	FPS	21947080
Intra	ITGA2	P17301	SHARPIN	Homo sapiens	Q9H0F6	Anti Bait CoIP	21947080
Intra	ITGA2	P17301	ITGB1	Homo sapiens	P05556	Lex-A Dimerization	14681217
Intra	ITGA2	P17301	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	10397731
Intra	ITGA2	P17301	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	21947080

Cross: Cross-species interaction Intra: Intraspecies interaction

ITGA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83362	Integrin alpha 2 Antibody (YA3107)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P84137	Integrin alpha 2 Antibody (YA3834)	ICC/IF, FC, ELISA	Human
HY-P84137A	Integrin alpha 2 Antibody (YA3834)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Fetal And Neonatal Alloimmune Thrombocytopenia	Nait Neonatal Alloimmune Thrombocytopenia Fnait
Bleeding Disorder, Platelet-Type, 9	Platelet-Type Bleeding Disorder 9 Glycoprotein Ia Deficiency BDPLT9 Gp Ia Deficiency Collagen Platelet Receptor Deficiency Bleeding Diathesis Due To Integrin Alpha2-Beta1 Deficiency Bleeding Disorder, Platelet Type 9
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial
Bleeding Disorder, Platelet-Type, 11	BDPLT11 Glycoprotein Vi Deficiency Gp Vi Deficiency Platelet-Type Bleeding Disorder 11 Bleeding Diathesis Due To A Collagen Receptor Defect Bleeding Diathesis Due To Glycoprotein Vi Deficiency Platelet-Type Bleeding Disorder-11 Bleeding Disorder, Platelet Type 11 Hemorrhage
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Thrombosis	Thrombosis Of Blood Vessel
Thrombasthenia
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type	Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome Smed-Sl Smed-Sl/Ac Smed Short Limb-Abnormal Calcification Type Smed Short Limb-Hand Type Spondylometaepiphyseal Dysplasia Short Limb-Hand Type Smed, Type Ii Smed Type 2 Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type Smed, Short Limb-Hand Type Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type Smed, Short Limb-Abnormal Calcification Type Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type SEMD-SL Smed Type Ii Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Rhabdomyosarcoma
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Arteriosclerosis	Arteriosclerotic Vascular Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Diabetes Mellitus	Diabetes
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06948	ITGA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06949	ITGA2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17109	Itga2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19782	Itga2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23554	Itga2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26279	Itga2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ITGA2	VGNC	VGNC:30313
Canis familiaris	ITGA2	VGNC	VGNC:42123
Felis catus	ITGA2	VGNC	VGNC:67839
Rattus norvegicus	ITGA2	RGD	RGD:621632
Macaca mulatta	ITGA2	VGNC	VGNC:73775
Mus musculus	ITGA2	MGD	MGI:96600
Others	ITGA2	NCBI