ADAM17 - ADAM metallopeptidase domain 17 Gene

Also Known as CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6868

About ADAM17

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,488,486-9,555,830 (from NCBI)

This gene has 28 transcripts (splice variants), 283 orthologues, 20 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 11.1), placenta (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous Other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral Infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020]

ADAM17 Products (7)

mRNA	Protein	Name
NM_021832.1
NM_003183.6	NP_003174.3	disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein
NM_001382778.1	NP_001369707.1	disintegrin and metalloproteinase domain-containing protein 17 isoform 3
XM_047445611.1	XP_047301567.1	disintegrin and metalloproteinase domain-containing protein 17 isoform X2
XM_047445612.1	XP_047301568.1	disintegrin and metalloproteinase domain-containing protein 17 isoform X2
XM_047445610.1	XP_047301566.1	disintegrin and metalloproteinase domain-containing protein 17 isoform X1
NM_001382777.1	NP_001369706.1	disintegrin and metalloproteinase domain-containing protein 17 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IDA IDA: Inferred from direct assay	24226769	GOA
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	12207026	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	12777399	GOA
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	24990881	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	14970227	GOA
enables interleukin-6 receptor binding	IPI IPI: Inferred from physical interaction	16034137	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	9774383	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	9034190	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	9774383	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	12777399	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12535668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9774383	GOA
enables tumor necrosis factor binding	IDA IDA: Inferred from direct assay	25049354	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Notch receptor processing	IDA IDA: Inferred from direct assay	24226769	GOA
involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	9774383	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	14970227	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	14970227	GOA
involved in cellular response to high density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	17786981	GOA
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	36476876	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	16034137	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	9034190	GOA
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	9034191	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21170088	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18483258	GOA
involved in positive regulation of T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	24813629	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	26617808	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	16034137	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	18483258	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17655843	GOA
involved in positive regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	12743035	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12777399	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24813629	GOA
involved in positive regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	24813629	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	9774383	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	24227843	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	18276953	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18383040	GOA
involved in signal release	IDA IDA: Inferred from direct assay	12777399	GOA
involved in wound healing, spreading of epidermal cells	IEP IEP: Inferred from expression pattern	14970227	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	17010968	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16034137	GOA
located in cell surface	IDA IDA: Inferred from direct assay	9034190	GOA
colocalizes with cell-cell junction	IDA IDA: Inferred from direct assay	14970227	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	14970227	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17010968	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17786981	GOA
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	14970227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM17 Protein Structure

Pep_M12B_propep

Reprolysin_5

Disintegrin

0
200
400
600
824 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 17	ADAM metallopeptidase domain 18 TNF-alpha convertase TNF-alpha convertase enzyme TNF-alpha converting enzyme a disintegrin and metalloproteinase 17 cartilage snake venom-like protease snake venom-like protease tumor necrosis factor, alpha, converting enzyme

ADAM17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAM17	P78536	DLG1	Homo sapiens	Q12959	Y2H Pooling	12668732
Intra	ADAM17	P78536	DLG1	Homo sapiens	Q12959	Anti Tag CoIP	12668732
Intra	ADAM17	P78536	DLG1	Homo sapiens	Q12959	Imaging	12668732
Intra	ADAM17	P78536	ITGB1	Homo sapiens	P05556	ELISA	22413019

Cross: Cross-species interaction Intra: Intraspecies interaction

ADAM17 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81817	ADAM17 Antibody (YA1562)	WB, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P84440	ADAM17 Antibody (YA4137)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P84440A	ADAM17 Antibody (YA4137)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Inflammatory Skin And Bowel Disease, Neonatal, 1	NISBD1
Coronavirus Infectious Disease
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Psoriasis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Neonatal Inflammatory Skin And Bowel Disease	Inflammatory Skin And Bowel Disease, Neonatal
Tylosis With Esophageal Cancer	Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome TOC Keratosis Palmaris Et Plantaris With Esophageal Cancer Bennion-Patterson Syndrome Howell-Evans Syndrome Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome Tylosis-Oesophageal Carcinoma Syndrome Palmoplantar Keratoderma With Esophageal Cancer Howel-Evans Syndrome Keratosis Palmoplantaris With Esophageal Cancer Tylosis - Oesophageal Carcinoma Howel-Evans' Syndrome
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Inflammatory Bowel Disease 18	IBD18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	99.30%	Unkown
HY-16657	TAPI-1	Inhibitor	99.36%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-120852	JG26	Inhibitor	98.14%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.54%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	Substrate	99.33%	Unkown
HY-175876	ADAM17-IN-1	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992406	MEDI-3622	Inhibitor	/	Unkown
HY-P992341	D8P1C1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAM17	RGD	RGD:620404
Felis catus	ADAM17	VGNC	VGNC:59577
Mus musculus	ADAM17	MGD	MGI:1096335
Canis familiaris	ADAM17	VGNC	VGNC:37576
Macaca mulatta	ADAM17	VGNC	VGNC:69478
Bos taurus	ADAM17	VGNC	VGNC:25607
Others	ADAM17	NCBI