1. Metabolic Enzyme/Protease
  2. MMP
  3. TAPI-1

TAPI-1 

Cat. No.: HY-16657 Purity: >99.0%
Handling Instructions

TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor.

For research use only. We do not sell to patients.

TAPI-1 Chemical Structure

TAPI-1 Chemical Structure

CAS No. : 163847-77-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 871 In-stock
Estimated Time of Arrival: December 31
1 mg USD 216 In-stock
Estimated Time of Arrival: December 31
5 mg USD 792 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1416 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE TAPI-1

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  • References

  • Customer Review

Description

TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins[1]. TAPI-1 is also a metalloproteinase (MMP) inhibitor[2].

IC50 & Target

TACE (ADAM17)[1], MMP[2]

In Vitro

TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells[1].
TAPI-1 attenuates oxidative stress and inflammatory cytokines[1]
LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LPS-treated HK-2 cells
Concentration: 1 µM
Incubation Time: 30 minutes (pre-treated)
Result: Increased cell viability.
Molecular Weight

499.60

Formula

C₂₆H₃₇N₅O₅

CAS No.

163847-77-6

SMILES

O=C(N[[email protected]@H](CC1=CC=C2C=CC=CC2=C1)C(N[[email protected]@H](C)C(NCCN)=O)=O)[[email protected]](CC(C)C)CC(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (62.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0016 mL 10.0080 mL 20.0160 mL
5 mM 0.4003 mL 2.0016 mL 4.0032 mL
10 mM 0.2002 mL 1.0008 mL 2.0016 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TAPI-1TAPI1TAPI 1MMPMatrix metalloproteinasesTACEADAM17metalloproteinaseTNF-αinflammatorydiseasesarthritisdiabetescancermultiple sclerosisAlzheimerInhibitorinhibitorinhibit

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Product Name:
TAPI-1
Cat. No.:
HY-16657
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