Mca-PLAQAV-Dpa-RSSSR-NH2
Based on 1 publication(s) in Google Scholar
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm).
For research use only. We do not sell to patients.
- Purity : 99.33%
- CAS No.: 192723-42-5
- Formula: C69H103N23O24
- Molecular Weight:1638.70
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mca-PLAQAV-Dpa-RSSSR-NH2
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Biological Activity
Description
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ADAM10 |
ADAM17 |
In Vitro
Mca-PLAQAV-Dpa-RSSSR-NH2 (10 μM; 20 min preincubation) acts as a FRET-based substrate for ADAM17, allowing measurement of ADAM17 protease activity via fluorescence intensity change[1].
Mca-PLAQAV-Dpa-RSSSR-NH2 (10-60 minutes; 6 hours) serves as a fluorescence substrate to measure TACE activity in HuH-7 cell extracts, detecting a significant SARS-S protein-induced increase in activity that is completely blocked by TAPI-2 (HY-100211) pretreatment[2].
Mca-PLAQAV-Dpa-RSSSR-NH2 (10 mM; 30 minutes) acts as a fluorogenic substrate for metalloprotease activity induced by active Hla in A431 keratinocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 192723-42-5
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Appearance Solid
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Molecular Weight 1638.70
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Formula C69H103N23O24
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Color Light yellow to yellow
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Sequence
{Mca}-Pro-Leu-Ala-Gln-Ala-Val-{Dpa}-Arg-Ser-Ser-Ser-Arg-NH2
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Sequence Shortening
{Mca}-PLAQAV-{Dpa}-RSSSR-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
A Multi-Channel Machine Learning Model for Predicting the Bioactivity Potential of Macrocyclic Peptides. [Abstract]2026 Jan 22;69(2):1628-1640. PMID: 41481784
Solvent & Solubility
In Vitro:
DMSO : 4.55 mg/mL (2.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6102 mL | 3.0512 mL | 6.1024 mL | 15.2560 mL |
Mca-PLAQAV-Dpa-RSSSR-NH2 Related Classifications
HY-P3722 Related Classifications
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