Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 

Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis^[1].

1752.72

C₆₉H₁₀₃N₂₃O₂₄.C₂HF₃O₂

Solid

Light yellow to yellow

{Mca}-Pro-Leu-Ala-Gln-Ala-Val-(Dpa)-Arg-Ser-Ser-Ser-Arg-NH2

{Mca}-PLAQAV-Dpa-RSSSR-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017.

  [2]. Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5.  [Content Brief]

  [3]. Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6.  [Content Brief]

  [4]. Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32.