Mca-PLAQAV-Dpa-RSSSR-NH2 TFA
Based on 1 publication(s) in Google Scholar
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm).
For research use only. We do not sell to patients.
- Purity : 99.54%
- Formula: C69H103N23O24.C2HF3O2
- Molecular Weight:1752.72
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mca-PLAQAV-Dpa-RSSSR-NH2 TFA
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Biological Activity
Description
IC50 & Target
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ADAM10 |
ADAM17 |
In Vitro
Mca-PLAQAV-Dpa-RSSSR-NH2 (10 μM; 20 min preincubation) TFA acts as a FRET-based substrate for ADAM17, allowing measurement of ADAM17 protease activity via fluorescence intensity change[1].
Mca-PLAQAV-Dpa-RSSSR-NH2 (10-60 minutes; 6 hours) TFA serves as a fluorescence substrate to measure TACE activity in HuH-7 cell extracts, detecting a significant SARS-S protein-induced increase in activity that is completely blocked by TAPI-2 (HY-100211) pretreatment[2].
Mca-PLAQAV-Dpa-RSSSR-NH2 (10 mM; 30 minutes) TFA acts as a fluorogenic substrate for metalloprotease activity induced by active Hla in A431 keratinocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1752.72
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Formula C69H103N23O24.C2HF3O2
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Color Light yellow to yellow
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Sequence
{Mca}-Pro-Leu-Ala-Gln-Ala-Val-(Dpa)-Arg-Ser-Ser-Ser-Arg-NH2
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Sequence Shortening
{Mca}-PLAQAV-Dpa-RSSSR-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
A Multi-Channel Machine Learning Model for Predicting the Bioactivity Potential of Macrocyclic Peptides. [Abstract]2026 Jan 22;69(2):1628-1640. PMID: 41481784
Solvent & Solubility
In Vitro:
H2O : 12.5 mg/mL (7.13 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5. [Content Brief]
[3]. Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.5705 mL | 2.8527 mL | 5.7054 mL | 14.2635 mL |
| 5 mM | 0.1141 mL | 0.5705 mL | 1.1411 mL | 2.8527 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA Related Classifications
HY-P3722A Related Classifications
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