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  3. GW280264X

GW280264X 

Cat. No.: HY-115670 Purity: 97.36%
Handling Instructions

GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.

For research use only. We do not sell to patients.

GW280264X Chemical Structure

GW280264X Chemical Structure

CAS No. : 866924-39-2

Size Price Stock Quantity
5 mg USD 430 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1580 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].

IC50 & Target[1]

ADAM17

8 nM (IC50)

ADAM10

11.5 nM (IC50)

In Vitro

The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Glioblastoma-initiating cells (GIC) GS-7 cells
Concentration: 0.1, 1, and 3 µM
Incubation Time: 48 hours
Result: Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17.
In Vivo

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[3]
Dosage: 100  µg/kg
Administration: I.p. injected; every day for one week starting 4 h post-surgery
Result: Showed significantly improved functional recovery compared to the control group.
Molecular Weight

575.72

Formula

C28H41N5O6S

CAS No.
SMILES

O=C(OCC1=CC=CC=C1)NCCCC[[email protected]](NC([[email protected]](CC(C)C)[[email protected]@H](N(C=O)O)CCC)=O)C(NC2=NC=CS2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (217.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7370 mL 8.6848 mL 17.3696 mL
5 mM 0.3474 mL 1.7370 mL 3.4739 mL
10 mM 0.1737 mL 0.8685 mL 1.7370 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.61 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
GW280264X
Cat. No.:
HY-115670
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