866924-39-2
Chemical Structure
GW280264X
- CAS No.: 866924-39-2
- Formula:C28H41N5O6S
- Molecular Weight:575.72
IUPAC Name: benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate
InChIKey: SKJLITFHSZNZMQ-SGNDLWITSA-N
SMILES: O=C(OCC1=CC=CC=C1)NCCCC[C@H](NC([C@H](CC(C)C)[C@@H](N(C=O)O)CCC)=O)C(NC2=NC=CS2)=O
Biological Activity: GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GW280264X | 99.30% | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. | ||||||||||||||||||||
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GW280264X (Standard) | ≥98% | GW280264X (Standard) is the analytical standard of GW280264X (HY-115670). This product is intended for research and analytical applications. GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. | ||||||||||||||||||||
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Similarity Score 0.56
HY-116171(Rac)-Calpain Inhibitor XII -
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HY-W106306H-Leu-Lys(Z)-OH -
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HY-W010783Boc-L-Lys(Z)-pNA -
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HY-P5027Cbz-Lys-Arg-pNA -
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HY-P1619ICI 186756 -
Similarity Score 0.53
HY-P4518Z-Val-Gly-Arg-pNA -
Similarity Score 0.53
HY-P4772Me-CO-Lys(Cbo)-Gly-Arg-pNA -
Similarity Score 0.53
HY-P4291Z-Leu-Leu-Tyr-COCHO -
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HY-P4500Z-Arg-Arg-pNA -
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References
- [1]. Christian Hundhausen, et al. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood. 2003 Aug 15;102(4):1186-95. [Content Brief]
- [2]. Fabian Wolpert, et al. A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. Neuro Oncol. 2014 Mar;16(3):382-91. [Content Brief]
