(Rac)-Calpain Inhibitor XII

Cat. No.: HY-116171 Pureté: 99.04%: Fiche technique
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(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, K_i=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, K_i=120 nM) and cathepsin B (K_i=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

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(Rac)-Calpain Inhibitor XII Chemical Structure

CAS No. : 181769-57-3

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtenir un devis
50 mg	Obtenir un devis

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	> 10 μM Compound: CI-XII	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by celltiter-blue assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by celltiter-blue assay	[PMID: 38630165]
Vero	CC₅₀	> 50 μM Compound: CI-XII	Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability incubated for 48 hrs by neutral red uptake assay Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability incubated for 48 hrs by neutral red uptake assay	[PMID: 38630165]

Masse moléculaire

482.57

Formule

C₂₆H₃₄N₄O₅

CAS No.

181769-57-3

Appearance

Solid

Color

White to yellow

SMILES

O=C(OCC1=CC=CC=C1)NC(C(NC(C(C(NCC2=NC=CC=C2)=O)=O)CCC)=O)CC(C)C

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvant et solubilité

In Vitro:

DMSO : 16 mg/mL (33.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0722 mL	10.3612 mL	20.7224 mL
5 mM	0.4144 mL	2.0722 mL	4.1445 mL
10 mM	0.2072 mL	1.0361 mL	2.0722 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.04%

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Fiche technique (267 KB) SDS (252 KB)

COA (245 KB) HNMR (117 KB) RP-HPLC (226 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Z Li, et al. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem. 1996 Sep 27;39(20):4089-98. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0722 mL	10.3612 mL	20.7224 mL	51.8060 mL
	5 mM	0.4144 mL	2.0722 mL	4.1445 mL	10.3612 mL
	10 mM	0.2072 mL	1.0361 mL	2.0722 mL	5.1806 mL
	15 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4537 mL
	20 mM	0.1036 mL	0.5181 mL	1.0361 mL	2.5903 mL
	25 mM	0.0829 mL	0.4144 mL	0.8289 mL	2.0722 mL
	30 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7269 mL