(Rac)-Calpain Inhibitor XII
Based on 1 Customer Validation
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
For research use only. We do not sell to patients.
- Purity : 99.04%
- CAS No.: 181769-57-3
- Formula: C26H34N4O5
- Molecular Weight:482.57
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
>10 μM
Compound: CI-XII
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by celltiter-blue assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by celltiter-blue assay
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[PMID: 38630165] |
| Vero | CC50 |
>50 μM
Compound: CI-XII
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Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability incubated for 48 hrs by neutral red uptake assay
Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability incubated for 48 hrs by neutral red uptake assay
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[PMID: 38630165] |
Chemical Information
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CAS No. 181769-57-3
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Appearance Solid
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Molecular Weight 482.57
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Formula C26H34N4O5
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Color White to yellow
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SMILES
O=C(OCC1=CC=CC=C1)NC(C(NC(C(C(NCC2=NC=CC=C2)=O)=O)CCC)=O)CC(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 16 mg/mL (33.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0722 mL | 10.3612 mL | 20.7224 mL | 51.8060 mL |
| 5 mM | 0.4144 mL | 2.0722 mL | 4.1445 mL | 10.3612 mL | |
| 10 mM | 0.2072 mL | 1.0361 mL | 2.0722 mL | 5.1806 mL | |
| 15 mM | 0.1381 mL | 0.6907 mL | 1.3815 mL | 3.4537 mL | |
| 20 mM | 0.1036 mL | 0.5181 mL | 1.0361 mL | 2.5903 mL | |
| 25 mM | 0.0829 mL | 0.4144 mL | 0.8289 mL | 2.0722 mL | |
| 30 mM | 0.0691 mL | 0.3454 mL | 0.6907 mL | 1.7269 mL |
(Rac)-Calpain Inhibitor XII Related Classifications
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