1. Metabolic Enzyme/Protease
  2. Proteasome
  3. (Rac)-Calpain Inhibitor XII

(Rac)-Calpain Inhibitor XII 

Cat. No.: HY-116171 Purity: ≥90.0%
Handling Instructions

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

For research use only. We do not sell to patients.

(Rac)-Calpain Inhibitor XII Chemical Structure

(Rac)-Calpain Inhibitor XII Chemical Structure

CAS No. : 181769-57-3

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Description

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury[1].

Molecular Weight

482.57

Formula

C₂₆H₃₄N₄O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 16 mg/mL (33.16 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0722 mL 10.3612 mL 20.7224 mL
5 mM 0.4144 mL 2.0722 mL 4.1445 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥90.0%

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(Rac)-Calpain Inhibitor XII
Cat. No.:
HY-116171
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