2882065-25-8
Chemical Structure
SJ995973
- CAS No.: 2882065-25-8
- Formula:C37H40ClN7O5S
- Molecular Weight:730.28
IUPAC Name: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(5-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)pentyl)acetamide
InChIKey: VVRONDSUSMJAEI-XIJSCUBXSA-N
SMILES: CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=O
Biological Activity: SJ995973 is a BRD4 PROTAC degrader with DC50 values of 0.87 nM (12 h) and 0.16 nM (24 h), respectively. SJ995973 induces the formation of a ternary complex between purified BRD4 and CRBN-DDB1 proteins, with an IC50 of 17 nM against CRBN. SJ995973 inhibits the viability of human acute myeloid leukemia cells. SJ995973 can be used in studies related to acute myeloid leukemia and medulloblastoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SJ995973 | 98.88% | SJ995973 is a BRD4 PROTAC degrader with DC50 values of 0.87 nM (12 h) and 0.16 nM (24 h), respectively. SJ995973 induces the formation of a ternary complex between purified BRD4 and CRBN-DDB1 proteins, with an IC50 of 17 nM against CRBN. SJ995973 inhibits the viability of human acute myeloid leukemia cells. SJ995973 can be used in studies related to acute myeloid leukemia and medulloblastoma. | ||||||||||||||||||||
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- [1]. Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angewandte Chemie (International ed. in English). 2021 Dec 13;60(51):26663-26670. [Content Brief]
- [2]. Actis M, et al. Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs. Journal of medicinal chemistry. 2025 Feb 13;68(3):3591-3611. [Content Brief]
Keywords
