1996636-69-1
Chemical Structure
CT-179
- CAS No.: 1996636-69-1
- Formula:C17H22Cl2N6O
- Molecular Weight:397.30
InChIKey: MWEZWAONAIZIAQ-UHFFFAOYSA-N
SMILES: CC1=NC(NC(NC2=CC(Cl)=C(C=C2)Cl)=O)=NC(NCCCN(C)C)=C1
Biological Activity: CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma[1].
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CT-179 | 99.79% | CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma. | ||||||||||||||||||||
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Keywords
