2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Thyroid Hormone Receptor Endogenous Metabolite
  4. Liothyronine sodium hydrate

Liothyronine sodium hydrate  (Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate)

Cat. No.: HY-A0070B Purity: 98.24%
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Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.

For research use only. We do not sell to patients.

CAS No. : 345957-19-9

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Based on 39 publication(s) in Google Scholar

Other Forms of Liothyronine sodium hydrate:

Liothyronine sodium hydrate Related Antibodies

Top Publications Citing Use of Products

39 Publications Citing Use of MCE Liothyronine sodium hydrate

WB
Cell Proliferation/Viability Assay
Cell Migration/Invasion Assay

    Liothyronine sodium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571.  [Abstract]

    PGC1α mRNA levels in TRβ‐overexpressing ccRCC cell lines versus controls following Triiodothyronine (T3) treatment (100 nM for 48 h).

    Liothyronine sodium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571.  [Abstract]

    CCK8 assay showing proliferation of TRβ-overexpressing cells treated with T3 (100 nM for 48 h).

    Liothyronine sodium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571.  [Abstract]

    Transwell assay results comparing the migration of TRβ-overexpressing cells with control cells in the presence of T3 (100 nM for 48 h).

    Liothyronine sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Nov 7;35(11):1915-1930.e8.  [Abstract]

    C3H10T1/2 preadipocytes were treated with differentiation medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nM Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days and subsequently cultured in maintaining medium supplemented with 1 nM Triiodothyronine, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were cultured in complete medium until used for experiments. Representative immunoblots of PGC-1α and UCP1 in beige adipocytes treated as indicated.

    Liothyronine sodium hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jun 2;14(1):3208.  [Abstract]

    C3H10T1/2 preadipocytes were cultured in DMEM supplemented with 10% FBS, 1% P/S. For adipogenic differentiation, confluent C3H10T1/2 preadipocytes were incubated with complete medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nm Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days. Then, cells were changed to the complete medium supplemented with 1 nM T3, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were maintained in complete medium until used for experiments. Representative immunoblots of NRP1 and EPHA7 in differentiated brown adipocytes transfected with si-Rbm3 or si-NC.

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    Description

    Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Liothyronine (T3, 100 nM) sodium hydrate stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine sodium hydrate binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine sodium hydrate promotes growth, induces differentiation and regualtes metabolic effects[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Liothyronine sodium hydrate Related Antibodies
    Formula

    C15H12I3NO4.xH2O.Na
    CAS No.
    Appearance

    Solid

    Color

    White to light brown

    SMILES

    N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O.[x].O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    1 M NaOH : ≥ 100 mg/mL

    H2O : 43.48 mg/mL (adjust pH to 11 with 1 M NaOH)

    *"≥" means soluble, but saturation unknown.

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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    Purity & Documentation

    Purity: 98.24%

    SDS (252 KB)

    COA (247 KB) HNMR (220 KB) LCMS (257 KB)

    Handling Instructions (2659 KB)
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    Liothyronine sodium hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Liothyronine sodium345957-19-9Triiodothyronine sodium3,3',5-Triiodo-L-thyronine sodiumT3 sodiumThyroid Hormone ReceptorEndogenous MetaboliteTHRthyroid hormoneTRαTRβInhibitorinhibitorinhibit

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