Liothyronine sodium hydrate (Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate)

Cat. No.: HY-A0070B: FAQs
Data Sheet Handling Instructions

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Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

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Liothyronine sodium hydrate Chemical Structure

CAS No. : 345957-19-9

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Other In-stock Forms of Liothyronine sodium hydrate:

Other Forms of Liothyronine sodium hydrate:

14 Publications Citing Use of MCE Liothyronine sodium hydrate

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Liothyronine (T3, 100 nM) sodium hydrate stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed^[1]. Liothyronine sodium hydrate binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine sodium hydrate promotes growth, induces differentiation and regualtes metabolic effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Formula

C₁₅H₁₂I₃NO₄.xH₂O.Na

CAS No.

345957-19-9

SMILES

N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O.[x].O

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [Content Brief]

[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. [Content Brief]

[3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. [Content Brief]

Liothyronine sodium hydrate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liothyronine sodium345957-19-9Triiodothyronine sodium3,3',5-Triiodo-L-thyronine sodiumT3 sodiumThyroid Hormone ReceptorEndogenous MetaboliteTHRthyroid hormoneTRαTRβInhibitorinhibitorinhibit

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