1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
    Apoptosis
  2. HDAC
    Autophagy
    Apoptosis
  3. CG-200745

CG-200745 

Cat. No.: HY-16138
Handling Instructions

CG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibits deacetylation of histone H3 and tubulin. CG200745 induces apoptosis.

For research use only. We do not sell to patients.

CG-200745 Chemical Structure

CG-200745 Chemical Structure

CAS No. : 936221-33-9

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Description

CG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibits deacetylation of histone H3 and tubulin. CG200745 induces apoptosis[1][2].

IC50 & Target[2]

HDAC

 

In Vitro

CG200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins[1][2].
CG-200745 (0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells[3].
CG-200745 (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in G2/M phase (69%)[3].
CG-200745 (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment[3].

Cell Proliferation Assay[3]

Cell Line: Calu6 cells
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Reduced the cell proliferation to 40% of untreated cells.

Cell Cycle Analysis[3]

Cell Line: Calu6 cells
Concentration: 3 μM
Incubation Time: 1, 8, 12, 24 hours
Result: Increased significantly cell proportion in G2/M phase (69%).

Western Blot Analysis[3]

Cell Line: Calu6 cells
Concentration: 0-10 μM
Incubation Time: 1, 4, 8, 12, 24 hours
Result: Increased the acetylation of histone H3 and H4 at various sites in a time-dependent manner.
In Vivo

CG-200745 (p.o.; 30 mg/kg/day; for 7 days) attenuates oxidative stress, inflammatory cytokines, and adhesion molecules in UUO kidneys[4].

Animal Model: Male 8-week-old C57BL/6 J mice weighing 20~22 g of unilateral ureteral obstruction (UUO)[4]
Dosage: 30 mg/kg
Administration: P.o.; daily; for 7 days
Result: Attenuated oxidative stress, inflammatory cytokines and adhesion molecules in UUO kidneys.
Molecular Weight

427.54

Formula

C₂₄H₃₃N₃O₄

CAS No.

936221-33-9

SMILES

O=C(NCCCN(C)C)/C(COC1=C2C=CC=CC2=CC=C1)=C/CCCCC(NO)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CG-200745
Cat. No.:
HY-16138
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