1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    MDM-2/p53
    Apoptosis
  3. Ivaltinostat formic

Ivaltinostat formic (Synonyms: CG-200745 formic)

Cat. No.: HY-16138A
Handling Instructions

Ivaltinostat (CG-200745) formic is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic induces apoptosis.

For research use only. We do not sell to patients.

Ivaltinostat formic Chemical Structure

Ivaltinostat formic Chemical Structure

Size Price Stock Quantity
5 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 5750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ivaltinostat (CG-200745) formic is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic induces apoptosis[1][2].

IC50 & Target[1]

HDAC

 

In Vitro

Ivaltinostat formic (CG-200745 formic; 0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells[3].
Ivaltinostat formic (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in G2/M phase (69%)[3].
Ivaltinostat formic (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Calu6 cells
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Reduced the cell proliferation to 40% of untreated cells.

Cell Cycle Analysis[3]

Cell Line: Calu6 cells
Concentration: 3 μM
Incubation Time: 1, 8, 12, 24 hours
Result: Increased significantly cell proportion in G2/M phase (69%).

Western Blot Analysis[3]

Cell Line: Calu6 cells
Concentration: 3 μM
Incubation Time: 1, 4, 8, 12, 24 hours
Result: Increased the acetylation of histone H3 and H4 at various sites in a time-dependent manner.
In Vivo

Ivaltinostat formic (CG-200745 formic; p.o.; 30 mg/kg/day; for 7 days) attenuates oxidative stress, inflammatory cytokines, and adhesion molecules in UUO kidneys[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 8-week-old C57BL/6 J mice weighing 20~22 g of unilateral ureteral obstruction (UUO)[4]
Dosage: 30 mg/kg
Administration: PO; daily; for 7 days
Result: Attenuated oxidative stress, inflammatory cytokines and adhesion molecules in UUO kidneys.
Molecular Weight

473.56

Formula

C₂₅H₃₅N₃O₆

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 250 mg/mL (527.92 mM; Need ultrasonic)

DMSO : 50 mg/mL (105.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1117 mL 10.5583 mL 21.1166 mL
5 mM 0.4223 mL 2.1117 mL 4.2233 mL
10 mM 0.2112 mL 1.0558 mL 2.1117 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Ivaltinostat formic
Cat. No.:
HY-16138A
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