1. GPCR/G Protein
  2. Leukotriene Receptor
  3. 12S-HHT

12S-HHT (Synonyms: 12(S)-HHTrE)

Cat. No.: HY-113330
Handling Instructions

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.

For research use only. We do not sell to patients.

12S-HHT Chemical Structure

12S-HHT Chemical Structure

CAS No. : 54397-84-1

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Description

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].

In Vitro

12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells[2].
12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis[2]. 12S-HHT is an endogenous agonist for BLT2[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HaCaT cells
Concentration: 0, 12.5, 25, 75 or 150 nM
Incubation Time: 3 hours
Result: UVB (5 mJ/cm2) irradiation markedly up-regulated IL-6 synthesis and release, which was suppressed by the treatment with 12-HHT in a concentration-dependent manner.
Molecular Weight

280.40

Formula

C₁₇H₂₈O₃

CAS No.
SMILES

CCCCC[[email protected]](O)/C=C/C=C/C/C=C\CCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

References

Purity: ≥99.0%

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Keywords:

12S-HHT12(S)-HHTrELeukotriene Receptorarachidonicacidmetabolismendogenousligandkeratinocytesanti-inflammatoryInhibitorinhibitorinhibit

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12S-HHT
Cat. No.:
HY-113330
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