54397-84-1
Chemical Structure
12S-HHT
Synonym(s): 12(S)-HHTrE
- CAS No.: 54397-84-1
- Formula:C17H28O3
- Molecular Weight:280.40
IUPAC Name: (S,5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid
InChIKey: KUKJHGXXZWHSBG-WBGSEQOASA-N
SMILES: CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O
Biological Activity: 12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].
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12S-HHT | 98.4% | 12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. | ||||||||||||||||||||
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- [1]. Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36. [Content Brief]
- [2]. Lee JW, et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44(6):378-386. [Content Brief]
Keywords
