2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species
  4. Oxaloacetic acid

Oxaloacetic acid  (Synonyms: 2-Oxosuccinic acid)

Cat. No.: HY-W010382 Purity: 99.88%
SDS
COA
Handling Instructions Technical Support

Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function.

For research use only. We do not sell to patients.

Oxaloacetic acid Chemical Structure

Oxaloacetic acid Chemical Structure

CAS No. : 328-42-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Oxaloacetic acid:

Oxaloacetic acid Related Antibodies

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Description

Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Oxaloacetic acid (10 mg/kg, i.p., daily for 3 d) significantly alleviates Paraquat (50 mg/kg, i.p.)-induced acute lung injury and improved the survival rate of Paraquat -poisoned mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

132.07

Formula

C4H4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(CC(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (757.17 mM)

DMSO : ≥ 100 mg/mL (757.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5717 mL 37.8587 mL 75.7174 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (757.17 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

SDS (476 KB)

COA (245 KB) HNMR (232 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.5717 mL 37.8587 mL 75.7174 mL 189.2935 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL 37.8587 mL
10 mM 0.7572 mL 3.7859 mL 7.5717 mL 18.9294 mL
15 mM 0.5048 mL 2.5239 mL 5.0478 mL 12.6196 mL
20 mM 0.3786 mL 1.8929 mL 3.7859 mL 9.4647 mL
25 mM 0.3029 mL 1.5143 mL 3.0287 mL 7.5717 mL
30 mM 0.2524 mL 1.2620 mL 2.5239 mL 6.3098 mL
40 mM 0.1893 mL 0.9465 mL 1.8929 mL 4.7323 mL
50 mM 0.1514 mL 0.7572 mL 1.5143 mL 3.7859 mL
60 mM 0.1262 mL 0.6310 mL 1.2620 mL 3.1549 mL
80 mM 0.0946 mL 0.4732 mL 0.9465 mL 2.3662 mL
100 mM 0.0757 mL 0.3786 mL 0.7572 mL 1.8929 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxaloacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxaloacetic acid328-42-72-Oxosuccinic acidEndogenous MetaboliteReactive Oxygen Speciesmetabolic,TCAcitric acid cyclegluconeogenesisurea cycleglyoxylate cycleamino acid synthesisfatty acid synthesisROSInhibitorinhibitorinhibit

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