Cat. No.: HY-W010382

Oxaloacetic acid

(Synonyms: 2-Oxosuccinic acid)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 328-42-7
Formula: C₄H₄O₅
Molecular Weight:132.07

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oxaloacetic acid Chemical Structure

CAS No.: 328-42-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vivo

Oxaloacetic acid (10 mg/kg, i.p., daily for 3 d) significantly alleviates Paraquat (50 mg/kg, i.p.)-induced acute lung injury and improved the survival rate of Paraquat -poisoned mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 328-42-7
Appearance Solid
Molecular Weight 132.07
Formula C₄H₄O₅
Color White to off-white
SMILES

O=C(O)C(CC(O)=O)=O
Synonyms

2-Oxosuccinic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cell Rep Med

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis. [Abstract]

2026 Feb 17;7(2):102616. PMID: 41672064
bioRxiv

2026 Jan 26.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (946.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.5717 mL

37.8587 mL

75.7174 mL

5 mM

1.5143 mL

7.5717 mL

15.1435 mL

10 mM

0.7572 mL

3.7859 mL

7.5717 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. F. L. Breusch. The fate of oxaloacetic acid in different organs. Biochem J. 1939 Nov; 33(11): 1757-1770. [Content Brief]

[2]. Brian D Fink, et al. Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem. 2018 Dec 21;293(51):19932-19941. [Content Brief]

[3]. Li W, et al. Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction. Front Pharmacol. 2022 Oct 13;13:1029775. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	7.5717 mL	37.8587 mL	75.7174 mL	189.2935 mL
	5 mM	1.5143 mL	7.5717 mL	15.1435 mL	37.8587 mL
	10 mM	0.7572 mL	3.7859 mL	7.5717 mL	18.9294 mL
	15 mM	0.5048 mL	2.5239 mL	5.0478 mL	12.6196 mL
	20 mM	0.3786 mL	1.8929 mL	3.7859 mL	9.4647 mL
	25 mM	0.3029 mL	1.5143 mL	3.0287 mL	7.5717 mL
	30 mM	0.2524 mL	1.2620 mL	2.5239 mL	6.3098 mL
	40 mM	0.1893 mL	0.9465 mL	1.8929 mL	4.7323 mL
	50 mM	0.1514 mL	0.7572 mL	1.5143 mL	3.7859 mL
	60 mM	0.1262 mL	0.6310 mL	1.2620 mL	3.1549 mL
	80 mM	0.0946 mL	0.4732 mL	0.9465 mL	2.3662 mL
	100 mM	0.0757 mL	0.3786 mL	0.7572 mL	1.8929 mL

Keywords

Oxaloacetic acid

2 Cited Publications

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Oxaloacetic acid

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Publications Citing Use of MedChemExpress (MCE) Oxaloacetic acid

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Oxaloacetic acid Related Classifications

HY-W010382 Related Classifications