Art. -Nr.: HY-W016814

(Z)-Aconitic acid

(Synonyms: cis-Aconitic acid)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout.

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Reinheit: 99.28%
CAS. Nr.: 585-84-2
Formel: C₆H₆O₆
Molecular Weight:174.11

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

(Z)-Aconitic acid Chemical Structure

CAS. Nr.: 585-84-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

(Z)-Aconitic acid (10-90 μM; 2 h) reduces TNF-α release and IκB-α phosphorylation in LPS-stimulated THP-1 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(Z)-Aconitic acid (10-90 mg/kg, p.o., 24 h after antigen challenge in AIA model or 15 h after MSU injection in gout model) inhibits Antigen-induced arthritis and Monosodium urate-induced gout in mice, reducing leukocyte accumulation in the joint cavity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6j male mice (8-10 weeks old) + antigen-induced arthritis (AIA) model or monosodium urate-induced gout model^[1]
Dosage:

10 mg/kg, 30 mg/kg, 90 mg/kg (0.5% w/v CMC suspension); 30 mg/kg (for gout model)
Administration:

Oral gavage, once, 24 h after antigen challenge in AIA model; Oral gavage, once, 15 h after MSU injection in gout model
Result:

Reduced total leukocytes and neutrophils in the synovial cavity and periarticular tissue, MPO activity, CXCL-1 levels in periarticular tissues, arthritis index, and hypernociception (AIA).
Significantly reduced total leukocyte and neutrophil accumulation into the synovial cavity at 30 mg/kg (gout model).

Chemical Information

CAS. Nr. 585-84-2
Appearance Solid
Molecular Weight 174.11
Formel C₆H₆O₆
Color White to light yellow
SMILES

O=C(O)/C([H])=C(C(O)=O)/CC(O)=O.
Synonyms

cis-Aconitic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

J Agric Food Chem

Pathway-Based Metabolomics Analysis Reveals Biosynthesis of Key Flavor Compounds in Mango. [Abstract]

2022 Aug 31;70(34):10389-10399. PMID: 34792344
Life Sci

Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]

2024 Jun 15:347:122682. PMID: 38702025

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (574.35 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (574.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.7435 mL

28.7175 mL

57.4350 mL

5 mM

1.1487 mL

5.7435 mL

11.4870 mL

10 mM

0.5743 mL

2.8717 mL

5.7435 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (574.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (557 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. de Oliveira DP, et al. cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice. Planta Med. 2022 Oct;88(13):1123-1131. [Content Brief]

[2]. Endo A, et al. Cis-and tram-aconitic acids as inhibitors of glutamate decarboxylase. Hoppe-Seyler’s Z. Physiol, 1977: 1365-1368.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	5.7435 mL	28.7175 mL	57.4350 mL	143.5874 mL
	5 mM	1.1487 mL	5.7435 mL	11.4870 mL	28.7175 mL
	10 mM	0.5743 mL	2.8717 mL	5.7435 mL	14.3587 mL
	15 mM	0.3829 mL	1.9145 mL	3.8290 mL	9.5725 mL
	20 mM	0.2872 mL	1.4359 mL	2.8717 mL	7.1794 mL
	25 mM	0.2297 mL	1.1487 mL	2.2974 mL	5.7435 mL
	30 mM	0.1914 mL	0.9572 mL	1.9145 mL	4.7862 mL
	40 mM	0.1436 mL	0.7179 mL	1.4359 mL	3.5897 mL
	50 mM	0.1149 mL	0.5743 mL	1.1487 mL	2.8717 mL
	60 mM	0.0957 mL	0.4786 mL	0.9572 mL	2.3931 mL
	80 mM	0.0718 mL	0.3590 mL	0.7179 mL	1.7948 mL
	100 mM	0.0574 mL	0.2872 mL	0.5743 mL	1.4359 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

(Z)-Aconitic acid

2 Cited Publications

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(Z)-Aconitic acid

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Publications Citing Use of MedChemExpress (MCE) (Z)-Aconitic acid

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(Z)-Aconitic acid Related Classifications

HY-W016814 Related Classifications