1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Acetyl Coenzyme A trisodium

Acetyl Coenzyme A trisodium (Synonyms: Acetyl-CoA trisodium)

Cat. No.: HY-113596
Handling Instructions

Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is a central metabolic intermediate. Acetyl Coenzyme A trisodium is the actual molecule through which glycolytic pyruvate enters the tricarboxylic acid (TCA) cycle, is a key precursor of lipid synthesis, and is the sole donor of the acetyl groups for acetylation. Acetyl Coenzyme A trisodium acts as a potent allosteric activator of pyruvate carboxylase (PC).

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Acetyl Coenzyme A trisodium Chemical Structure

Acetyl Coenzyme A trisodium Chemical Structure

CAS No. : 102029-73-2

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Description

Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is a central metabolic intermediate. Acetyl Coenzyme A trisodium is the actual molecule through which glycolytic pyruvate enters the tricarboxylic acid (TCA) cycle, is a key precursor of lipid synthesis, and is the sole donor of the acetyl groups for acetylation. Acetyl Coenzyme A trisodium acts as a potent allosteric activator of pyruvate carboxylase (PC)[1].

In Vitro

Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant molecule constituted by an acetyl moiety (CH3CO) linked to coenzyme A (CoA), a derivative of vitamin B5 and cysteine, through a thioester bond. As thioester bonds are energy rich, the chemical structure of acetyl-CoA facilitates the transfer of the acetyl moiety to a variety of acceptor molecules, including amino groups on proteins[1].
In most mammalian cells, Acetyl-coenzyme A (Acetyl-CoA) is predominantly generated in the mitochondrial matrix by various metabolic circuitries, namely glycolysis, β-oxidation, and the catabolism of branched amino acids. Cytosolic Acetyl-coenzyme A is the precursor of multiple anabolic reactions that underlie the synthesis of fatty acids and steroids, as well as specific amino acids including glutamate, proline, and arginine[1].

In Vivo

Mice deprived of food (but with access to water ad libitum) for 24 hr exhibit a significant reduction in total Acetyl-coenzyme A (Acetyl-CoA) levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl-coenzyme A concentrations in the brain and actually increase hepatic Acetyl-coenzyme A and protein acetylation levels. Ethanol intake augments Acetyl-coenzyme A levels in hepatic mitochondria[1].

Molecular Weight

875.52

Formula

C₂₃H₃₅N₇Na₃O₁₇P₃S

CAS No.

102029-73-2

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(OCC(C)([[email protected]@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O[Na])=O)(O)=O)[[email protected]]1OP(O[Na])(O[Na])=O)N2C3=C(C(N)=NC=N3)N=C2

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Keywords:

Acetyl Coenzyme A trisodiumAcetyl-CoA trisodiumEndogenous MetabolitePyruvatecarboxylasesecondmessengerintermediateTCAprecursorInhibitorinhibitorinhibit

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