Cat. No.: HY-113596

Acetyl Coenzyme A trisodium

(Synonyms: Acetyl-CoA trisodium)

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.

For research use only. We do not sell to patients.

Purity: 99.22%
CAS No.: 102029-73-2
Formula: C₂₃H₃₅N₇Na₃O₁₇P₃S
Molecular Weight:875.52

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Acetyl Coenzyme A trisodium Chemical Structure

CAS No.: 102029-73-2

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

Acetyl coenzyme A trisodium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A trisodium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetyl coenzyme A trisodium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy^[2]^[3]. Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A trisodium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A trisodium concentrations in the brain and actually increase hepatic Acetyl coenzyme A trisodium and protein acetylation levels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 102029-73-2
Appearance Solid
Molecular Weight 875.52
Formula C₂₃H₃₅N₇Na₃O₁₇P₃S
Color White to off-white
SMILES

O=P(OCC([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(C)C)(O)OP(OC[C@@H]1[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O
Synonyms

Acetyl-CoA trisodium
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (7)

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Journal Impact Factor

Cancer Res

A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. [Abstract]

2025 Sep 3. PMID: 40900036
Bone Res

Osteoclasts control endochondral ossification via regulating acetyl-CoA availability. [Abstract]

2024 Aug 28;12(1):49. PMID: 39198395
Sci Adv

mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy. [Abstract]

2026 May 15;12(20):eadz3835. PMID: 42139339
Cell Rep

Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. [Abstract]

2025 Jan 10;44(1):115203. PMID: 39799570
Chin Med

Chuangling Ye mitigates diabetic foot ulcer through suppressing keratinocyte ferroptosis via inhibiting ACSS2/ACSL4 axis. [Abstract]

2026 Jun 8;21(1):162. PMID: 42260608
J Cell Physiol

Identification of key events and regulatory networks in the formation process of primordial germ cell based on proteomics. [Abstract]

2023 Mar;238(3):610-630. PMID: 36745473
bioRxiv

A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling. [Abstract]

2026 May 20:2026.05.19.726225. PMID: 42239474

Solvent & Solubility

In Vitro:

H₂O : 83.33 mg/mL (95.18 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1422 mL

5.7109 mL

11.4218 mL

5 mM

0.2284 mL

1.1422 mL

2.2844 mL

10 mM

0.1142 mL

0.5711 mL

1.1422 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (114.22 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. [Content Brief]

[2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. [Content Brief]

[3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. [Content Brief]

[4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.1422 mL	5.7109 mL	11.4218 mL	28.5545 mL
	5 mM	0.2284 mL	1.1422 mL	2.2844 mL	5.7109 mL
	10 mM	0.1142 mL	0.5711 mL	1.1422 mL	2.8554 mL
	15 mM	0.0761 mL	0.3807 mL	0.7615 mL	1.9036 mL
	20 mM	0.0571 mL	0.2855 mL	0.5711 mL	1.4277 mL
	25 mM	0.0457 mL	0.2284 mL	0.4569 mL	1.1422 mL
	30 mM	0.0381 mL	0.1904 mL	0.3807 mL	0.9518 mL
	40 mM	0.0286 mL	0.1428 mL	0.2855 mL	0.7139 mL
	50 mM	0.0228 mL	0.1142 mL	0.2284 mL	0.5711 mL
	60 mM	0.0190 mL	0.0952 mL	0.1904 mL	0.4759 mL
	80 mM	0.0143 mL	0.0714 mL	0.1428 mL	0.3569 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Acetyl Coenzyme A trisodium

7 Cited Publications

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Acetyl Coenzyme A trisodium

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Publications Citing Use of MedChemExpress (MCE) Acetyl Coenzyme A trisodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (7)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Acetyl Coenzyme A trisodium Related Classifications

HY-113596 Related Classifications