2. Others Metabolic Enzyme/Protease Autophagy
  3. Oxidative Phosphorylation Endogenous Metabolite Autophagy
  4. Acetyl Coenzyme A trisodium

Acetyl Coenzyme A trisodium  (Synonyms: Acetyl-CoA trisodium)

Cat. No.: HY-113596 Purity: 95.14%
COA Handling Instructions

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Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.

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Acetyl Coenzyme A trisodium Chemical Structure

Acetyl Coenzyme A trisodium Chemical Structure

CAS No. : 102029-73-2

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1 mg USD 68 In-stock
5 mg USD 150 In-stock
10 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Acetyl Coenzyme A trisodium:

Acetyl Coenzyme A trisodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Acetyl Coenzyme A trisodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Acetyl coenzyme A trisodium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A trisodium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetyl Coenzyme A trisodium Related Antibodies
In Vivo

Acetyl coenzyme A trisodium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].? Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A trisodium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A trisodium concentrations in the brain and actually increase hepatic Acetyl coenzyme A trisodium and protein acetylation levels[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

875.52

Formula

C23H35N7Na3O17P3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OCC([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(C)C)(O)OP(OC[C@@H]1[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (95.18 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1422 mL 5.7109 mL 11.4218 mL
5 mM 0.2284 mL 1.1422 mL 2.2844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (114.22 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.14%

COA (249 KB) HNMR (302 KB) CNMR (363 KB) RP-HPLC (204 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1422 mL 5.7109 mL 11.4218 mL 28.5545 mL
5 mM 0.2284 mL 1.1422 mL 2.2844 mL 5.7109 mL
10 mM 0.1142 mL 0.5711 mL 1.1422 mL 2.8554 mL
15 mM 0.0761 mL 0.3807 mL 0.7615 mL 1.9036 mL
20 mM 0.0571 mL 0.2855 mL 0.5711 mL 1.4277 mL
25 mM 0.0457 mL 0.2284 mL 0.4569 mL 1.1422 mL
30 mM 0.0381 mL 0.1904 mL 0.3807 mL 0.9518 mL
40 mM 0.0286 mL 0.1428 mL 0.2855 mL 0.7139 mL
50 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5711 mL
60 mM 0.0190 mL 0.0952 mL 0.1904 mL 0.4759 mL
80 mM 0.0143 mL 0.0714 mL 0.1428 mL 0.3569 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acetyl Coenzyme A trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetyl Coenzyme A trisodium102029-73-2Acetyl-CoA trisodiumOxidative PhosphorylationEndogenous MetaboliteAutophagyPTMsphosphorylation metabolismTCAacetyl groupsacetylationautophagyU2OS cellsInhibitorinhibitorinhibit

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