Acetyl coenzyme A lithium
Based on 7 publication(s) in Google Scholar
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis.
For research use only. We do not sell to patients.
- Purity: 93.25%
- CAS No.: 32140-51-5
- Formula: C23H38N7O17P3S
- Molecular Weight:809.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Acetyl coenzyme A lithium
More- Cancer Res. 2025 Sep 3. [Abstract]
- Bone Res. 2024 Aug 28;12(1):49. [Abstract]
- Sci Adv. 2026 May 15;12(20):eadz3835. [Abstract]
- Cell Rep. 2025 Jan 10;44(1):115203. [Abstract]
- Chin Med. 2026 Jun 8;21(1):162. [Abstract]
- J Cell Physiol. 2023 Mar;238(3):610-630. [Abstract]
- bioRxiv. 2026 May 20:2026.05.19.726225. [Abstract]
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Acetyl coenzyme A lithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A lithium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 32140-51-5
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Appearance Solid
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Molecular Weight 809.57
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Formula C23H38N7O17P3S
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Color White to off-white
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SMILES
O=P(OCC([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(C)C)(O)OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O.[xLi]
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Synonyms
Acetyl-CoA lithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Cancer Res
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. [Abstract]2025 Sep 3. PMID: 40900036 -
Bone Res
2024 Aug 28;12(1):49. PMID: 39198395 -
Sci Adv
mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy. [Abstract]2026 May 15;12(20):eadz3835. PMID: 42139339 -
Cell Rep
Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. [Abstract]2025 Jan 10;44(1):115203. PMID: 39799570 -
Chin Med
Chuangling Ye mitigates diabetic foot ulcer through suppressing keratinocyte ferroptosis via inhibiting ACSS2/ACSL4 axis. [Abstract]2026 Jun 8;21(1):162. PMID: 42260608 -
J Cell Physiol
Identification of key events and regulatory networks in the formation process of primordial germ cell based on proteomics. [Abstract]2023 Mar;238(3):610-630. PMID: 36745473 -
bioRxiv
A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling. [Abstract]2026 May 20:2026.05.19.726225. PMID: 42239474
Solvent & Solubility
H2O : ≥ 50 mg/mL (61.76 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. [Content Brief]
[2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. [Content Brief]
[3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. [Content Brief]
[4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2352 mL | 6.1761 mL | 12.3522 mL | 30.8806 mL |
| 5 mM | 0.2470 mL | 1.2352 mL | 2.4704 mL | 6.1761 mL | |
| 10 mM | 0.1235 mL | 0.6176 mL | 1.2352 mL | 3.0881 mL | |
| 15 mM | 0.0823 mL | 0.4117 mL | 0.8235 mL | 2.0587 mL | |
| 20 mM | 0.0618 mL | 0.3088 mL | 0.6176 mL | 1.5440 mL | |
| 25 mM | 0.0494 mL | 0.2470 mL | 0.4941 mL | 1.2352 mL | |
| 30 mM | 0.0412 mL | 0.2059 mL | 0.4117 mL | 1.0294 mL | |
| 40 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.7720 mL | |
| 50 mM | 0.0247 mL | 0.1235 mL | 0.2470 mL | 0.6176 mL | |
| 60 mM | 0.0206 mL | 0.1029 mL | 0.2059 mL | 0.5147 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetyl coenzyme A lithium Related Classifications
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