TCA Cycle Metabolite Compound Library
Based on 78 publication(s) in Google Scholar
The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins.
For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future.
MCE supplies a unique collection of 26 key intermediates of the TCA cycle, which can be utilized for TCA-related research and metabolomics identification studies.
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Description & Advantages
• A useful tool for TCA cycle related diseases drugs discovery.
• Target diverse, medicinally active and cell permeable.
• Bioactivity and safety confirmed by preclinical research and clinical trials.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• High purity and quality validated by NMR and LC/MS.
Product Details
A collection of 26 TCA cycle metabolite compounds supplied as pre-dissolved Solutions or Solid
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Publications (78)
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Journal Impact Factor
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Most Recent
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Chem Rev
2020 Oct 28;120(20):11616-11650. PMID: 32930577 -
Signal Transduct Target Ther
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis. [Abstract]2025 Oct 7;10(1):333. PMID: 41052986 -
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Med
2017 Apr 7;23(4):405-408. PMID: 28388612 -
Circulation
Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth. [Abstract]2022 Apr 12;145(15):1154-1168. PMID: 35317609 -
Mol Cell
2025 Jul 3;85(13):2581-2596.e6. PMID: 40555234 -
Nat Commun
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. [Abstract]2026 May 5;17(1):4062. PMID: 42086561 -
Nat Commun
2025 Nov 13;16(1):9860. PMID: 41233320 -
Nat Commun
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. [Abstract]2020 Sep 4;11(1):4417. PMID: 32887884 -
Nat Commun
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. [Abstract]2018 Apr 26;9(1):1677. PMID: 29700304 -
Acta Pharm Sin B
Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]2021 Jan;11(1):143-155. PMID: 33532186 -
Adv Sci (Weinh)
Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin-induced Intestinal Injury by Production of Carboxylesterase EstB. [Abstract]2025 Dec 12:e17747. PMID: 41387308 -
J Adv Res
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria. [Abstract]2025 Jan 9:S2090-1232(24)00621-0. PMID: 39793961 -
Sci Adv
Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]2026 Jun 12;12(24):eaed2731. PMID: 42284421 -
J Biomed Sci
STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening. [Abstract]2018 Aug 2;25(1):60. PMID: 30068339 -
Arthritis Rheumatol
Deficiency of cartilage-specific Y-box binding protein 1 represses NF-κB signaling and alleviates osteoarthritis progression. [Abstract]2025 Jul 14. PMID: 40654155 -
Cancer Lett
2026 Apr 1:642:218300. PMID: 41651400 -
Proc Natl Acad Sci U S A
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma. [Abstract]2025 Sep 30;122(39):e2519568122. PMID: 40991439 -
EMBO Mol Med
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer. [Abstract]2022 Apr 7;14(4):e14608. PMID: 34927798 -
Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
Emerg Microbes Infect
A novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle. [Abstract]2024 Jun 12:2368217. PMID: 38865205 -
Cell Chem Biol
An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels. [Abstract]2025 Nov 20;32(11):1381-1396.e8. PMID: 41218609 -
Cell Death Discov
2023 Dec 1;9(1):435. PMID: 38040674 -
Cell Rep
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. [Abstract]2017 Jul 25;20(4):999-1015. PMID: 28746882 -
Clin Transl Med
Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer. [Abstract]2025 Feb;15(2):e70078. PMID: 39856363 -
J Med Chem
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions. [Abstract]2018 Jan 11;61(1):360-371. PMID: 29240409 -
Anal Chem
Longitudinal Fragment Profiles Based on Multi-Collision Energy Tandem Mass Spectra Improve the Accuracy of Metabolite Identification in Untargeted Metabolomics. [Abstract]2025 Jul 15;97(27):14349-14360. PMID: 40592760 -
J Invest Dermatol
Combined Cyclin-Dependent Kinase Inhibition Overcomes MAPK/Extracellular Signal-Regulated Kinase Kinase Inhibitor Resistance in Plexiform Neurofibroma of Neurofibromatosis Type I. [Abstract]2022 Mar;142(3 Pt A):613-623.e7. PMID: 34534577 -
J Cheminform
HAMdb: a database of human autophagy modulators with specific pathway and disease information. [Abstract]2018 Jul 31;10(1):34. PMID: 30066211 -
Biochem Pharmacol
Givinostat rescues folding of cystathionine beta-synthase and ameliorates murine homocystinuria. [Abstract]2025 Jun 24:239:117079. PMID: 40571220 -
Biochem Pharmacol
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia. [Abstract]2023 Nov:217:115809. PMID: 37717691 -
Life Sci
Identification of novel CDK 9 inhibitors based on virtual screening, molecular dynamics simulation, and biological evaluation. [Abstract]2020 Oct 1;258:118228. PMID: 32781071 -
Front Pharmacol
CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling. [Abstract]2020 Nov 11;11:580407. PMID: 33343350 -
Bioorg Chem
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation. [Abstract]2023 Dec:141:106880. PMID: 37783098 -
Nanomedicine
Improving lipid nanoparticles delivery efficiency of macrophage cells by using immunomodulatory small molecules. [Abstract]2025 Feb 3:64:102809. PMID: 39904398 -
Int J Antimicrob Agents
Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo. [Abstract]2024 Aug 5:107285. PMID: 39111708 -
J Med Virol
Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion. [Abstract]2021 Oct;93(10):5825-5832. PMID: 34061377 -
iScience
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase. [Abstract]2024 Sep 16;27(10):110967. PMID: 39429773 -
Sci Rep
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. [Abstract]2017 Oct 16;7(1):12881. PMID: 29038464 -
ACS Infect Dis
Repurposing GSK2018682 Confers Dual Antibacterial and Antibiofilm Activity against Staphylococcus aureus. [Abstract]2026 Feb 13;12(2):623-636. PMID: 41525229 -
ACS Chem Biol
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. [Abstract]2016 Dec 16;11(12):3400-3411. PMID: 27768280 -
ACS Chem Biol
2016 May 20;11(5):1245-54. PMID: 26863403 -
Epigenetics Chromatin
2020 Aug 3;13(1):31. PMID: 32746900 -
Toxicol Appl Pharmacol
Drug screening reveals the mechanism of toyocamycin-induced apoptosis in triple-negative breast cancer organoids. [Abstract]2026 Jan:506:117659. PMID: 41314261 -
J Comput Aided Mol Des
Synergistic approach utilizing bioinformatics, machine learning, and traditional screening for the identification of novel CSK inhibitors targeting hepatocellular carcinoma. [Abstract]2025 Nov 8;39(2):119. PMID: 41204015 -
ChemistryOpen
Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations. [Abstract]2025 Sep 7:e202500360. PMID: 40914945 -
Bioorg Med Chem
Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]2025 Sep 27:131:118423. PMID: 41033076 -
Biol Reprod
Strong inhibition of neutrophil-sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors. [Abstract]2017 Nov 1;97(5):671-687. PMID: 29036279 -
SLAS Discov
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites. [Abstract]2026 Feb 17:39:100298. PMID: 41713554 -
J Am Soc Mass Spectrom
2026 Jan 7;37(1):8-12. PMID: 41324382 -
SLAS Discov
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates. [Abstract]2025 Apr:32:100224. PMID: 40024444 -
SLAS Discov
2020 Sep;25(8):895-905. PMID: 32567455 -
PLoS One
Antibiofilm and antibacterial activity of maslinic acid against Vancomycin-Resistant Enterococci (VRE). [Abstract]2026 Feb 10;21(2):e0342234. PMID: 41666236 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Reprod Biol
Novel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis. [Abstract]2025 Jan 11;25(1):100992. PMID: 39799809 -
Biol Open
2026 Feb 15;15(2):bio062380. PMID: 41601273 -
In Vitro Cell Dev Biol Anim
The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. [Abstract]2016 Apr;52(4):488-96. PMID: 26822431 -
bioRxiv
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA. [Abstract]2026 Jun 5:2026.06.02.729650. PMID: 42282735 -
bioRxiv
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. [Abstract]2023 May 10:2021.05.15.444128. PMID: 34159337 -
bioRxiv
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. [Abstract]2020 Dec 7:2020.05.27.117184. PMID: 32577649 -
Acta Med Iran
Precision Medicine Approach to Anaplastic Thyroid Cancer: Advances in Targeted Drug Therapy Based on Specific Signaling Pathways. [Abstract]2017 Mar;55(3):200-208. PMID: 28282720 -
J Biomol Screen
Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells. [Abstract]2015 Oct;20(9):1074-83. PMID: 26245650 -
Chem Biol
Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles. [Abstract]2015 Aug 20;22(8):1144-55. PMID: 26211361
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Bacterial (3)
Apoptosis (2)
Ferroptosis (2)
NF-κB (2)
p38 MAPK (2)
Antibiotic (1)
Autophagy (1)
HSV (1)
NO Synthase (1)
Parasite (1)
Tyrosinase (1)