(S)-2-aminopentanedioic acid hydrochloride
Based on 13 publication(s) in Google Scholar
(S)-2-aminopentanedioic acid hydrochloride is a glutamic acid derivative.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 138-15-8
- Formula: C5H10ClNO4
- Molecular Weight:183.59
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S)-2-aminopentanedioic acid hydrochloride
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- Adv Sci (Weinh). 2025 Oct 5:e11194. [Abstract]
- Adv Sci (Weinh). 2025 Feb;12(6):e2411479. [Abstract]
- J Transl Med. 2024 Feb 18;22(1):178. [Abstract]
- Cancer Immunol Immunother. 2025 Jun 7;74(8):240. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
- Neurochem Int. 2023 Oct:169:105587. [Abstract]
- Neuropharmacology. 2025 Jun 15:271:110405. [Abstract]
- J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]
- Amino Acids. 2024 Sep 18;56(1):56. [Abstract]
- Fitoterapia. 2026 Apr:190:107182. [Abstract]
- Physiol Rep. 2026 Jun;14(11):e70975. [Abstract]
Customer Validation & Images
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Bio/Physico-chemical Assay
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Flow Cytometry
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Cell Proliferation/Viability Assay
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RT-PCR
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Cell Imaging/Staining
Biological Activity
Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 138-15-8
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Appearance Solid
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Molecular Weight 183.59
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Formula C5H10ClNO4
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
Adv Sci (Weinh)
Assessing the Nature of Human Brain-Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air-liquid Microfluidic Platform. [Abstract]2025 Oct 5:e11194. PMID: 41047484
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 5:e11194. [Abstract]
L-Glutamic acid (100 µM; 10 min) for activation of spike count. Spontaneous LFP activity is recorded from OPAB that has been pre-treated with Bicuculline and stimulated with L-Glutamic acid. The LFP signal from the activated OPAB is measured (pre), and then the electrical signal is inhibited for 10 min using a cocktail of TTX, CNQX, and AP5 and LFP was recorded again (post).
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Adv Sci (Weinh)
Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency. [Abstract]2025 Feb;12(6):e2411479. PMID: 39680480 -
J Transl Med
HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1. [Abstract]2024 Feb 18;22(1):178. PMID: 38369471
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 18;22(1):178. [Abstract]
PC3 and DU145 cells were treated with 10 μM glutamate for 24 h, after which the protein expression levels were analysed by western blotting. The expression intensity was normalized to that of β-tubulin (right panel).
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Cancer Immunol Immunother
2025 Jun 7;74(8):240. PMID: 40481876
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jun 7;74(8):240. [Abstract]
Flow cytometry representative image showing the effect of exogenous glutamate (1 mM) on mouse primary T cells.
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Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2026 Feb 1:170:116080. PMID: 41429063 -
Neurochem Int
Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation. [Abstract]2023 Oct:169:105587. PMID: 37495172 -
Neuropharmacology
Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis. [Abstract]2025 Jun 15:271:110405. PMID: 40057176 -
J Inflamm Res
Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice. [Abstract]2025 Jan 27:18:1235-1254. PMID: 39897526
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]
Viability of HT22 cells treated with Glutamate at different concentrations (0, 5, 10, 15, 20 and 25 mM) for 24 h (n=5 at each concentration).
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]
The relative mRNA expression levels of c-fos in the control, glu (20 mM, 24 h) and lactate groups (n=6 in each group).
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]
Fluorescence images of TUNEL staining of HT22 cells in the control, glu (20 mM, 24 h) and lactate groups.
(S)-2-aminopentanedioic acid hydrochloride purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]
Images of VGLUT1 fluorescence staining in HT22 cells from the control, glu (20 mM, 24 h) and lactate groups.
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Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
Fitoterapia
The stem-derived bioactive fraction of Syringa oblata Lindl. Ameliorates insomnia via cAMP signaling-mediated regulation of neurotransmission, oxidative stress, and inflammation: A multi-omics study. [Abstract]2026 Apr:190:107182. PMID: 41861857 -
Physiol Rep
Monosodium glutamate-mediated Ca2+-dependent intestinal epithelial ion transports in health and IBS-D in male mice. [Abstract]2026 Jun;14(11):e70975. PMID: 42281391
Solvent & Solubility
DMSO : 100 mg/mL (544.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4469 mL | 27.2346 mL | 54.4692 mL | 136.1730 mL |
| 5 mM | 1.0894 mL | 5.4469 mL | 10.8938 mL | 27.2346 mL | |
| 10 mM | 0.5447 mL | 2.7235 mL | 5.4469 mL | 13.6173 mL | |
| 15 mM | 0.3631 mL | 1.8156 mL | 3.6313 mL | 9.0782 mL | |
| 20 mM | 0.2723 mL | 1.3617 mL | 2.7235 mL | 6.8086 mL | |
| 25 mM | 0.2179 mL | 1.0894 mL | 2.1788 mL | 5.4469 mL | |
| 30 mM | 0.1816 mL | 0.9078 mL | 1.8156 mL | 4.5391 mL | |
| 40 mM | 0.1362 mL | 0.6809 mL | 1.3617 mL | 3.4043 mL | |
| 50 mM | 0.1089 mL | 0.5447 mL | 1.0894 mL | 2.7235 mL | |
| 60 mM | 0.0908 mL | 0.4539 mL | 0.9078 mL | 2.2695 mL | |
| 80 mM | 0.0681 mL | 0.3404 mL | 0.6809 mL | 1.7022 mL | |
| 100 mM | 0.0545 mL | 0.2723 mL | 0.5447 mL | 1.3617 mL |
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