2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. D-Glutamic acid

D-Glutamic acid  (Synonyms: (R)-Glutamic acid)

Cat. No.: HY-100805 Purity: ≥98.0%
COA Handling Instructions

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

For research use only. We do not sell to patients.

D-Glutamic acid Chemical Structure

D-Glutamic acid Chemical Structure

CAS No. : 6893-26-1

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Based on 1 publication(s) in Google Scholar

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Description

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

147.13

Appearance

Solid

Formula

C5H9NO4
CAS No.
SMILES

N[[email protected]](CCC(O)=O)C(O)=O
Structure Classification
Source

Escherichia coli
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 13 mg/mL (88.36 mM; ultrasonic and adjust pH to 3 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (67.97 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥99.0%

COA (304 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[3]

Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

D-Glutamic acid6893-26-1(R)-Glutamic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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