1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. D-Glutamic acid

D-Glutamic acid (Synonyms: (R)-Glutamic acid)

Cat. No.: HY-100805 Purity: >99.0%
Handling Instructions

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

For research use only. We do not sell to patients.

D-Glutamic acid Chemical Structure

D-Glutamic acid Chemical Structure

CAS No. : 6893-26-1

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Based on 1 publication(s) in Google Scholar

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Description

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2].

In Vivo

D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3].

Molecular Weight

147.13

Formula

C₅H₉NO₄

CAS No.

6893-26-1

SMILES

N[[email protected]](CCC(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 6 mg/mL (40.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >99.0%

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Keywords:

D-Glutamic acid(R)-Glutamic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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D-Glutamic acid
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