D-Glutamic acid-d5
Based on 1 Customer Validation
D-Glutamic acid-d5 is the deuterium labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 14341-88-9
- Formula: C5H4D5NO4
- Molecular Weight:152.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 14341-88-9
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Unlabeled Cas 6893-26-1
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Appearance Solid
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Molecular Weight 152.16
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Formula C5H4D5NO4
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Color White to off-white
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SMILES
OC(C([2H])([2H])C([2H])([2H])[C@](N)([2H])C(O)=O)=O
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Synonyms
(R)-Glutamic acid-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (328.60 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. [Content Brief]
[3]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. [Content Brief]
[4]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.5720 mL | 32.8601 mL | 65.7203 mL | 164.3007 mL |
| 5 mM | 1.3144 mL | 6.5720 mL | 13.1441 mL | 32.8601 mL | |
| 10 mM | 0.6572 mL | 3.2860 mL | 6.5720 mL | 16.4301 mL | |
| 15 mM | 0.4381 mL | 2.1907 mL | 4.3814 mL | 10.9534 mL | |
| 20 mM | 0.3286 mL | 1.6430 mL | 3.2860 mL | 8.2150 mL | |
| 25 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 6.5720 mL | |
| 30 mM | 0.2191 mL | 1.0953 mL | 2.1907 mL | 5.4767 mL | |
| 40 mM | 0.1643 mL | 0.8215 mL | 1.6430 mL | 4.1075 mL | |
| 50 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 3.2860 mL | |
| 60 mM | 0.1095 mL | 0.5477 mL | 1.0953 mL | 2.7383 mL | |
| 80 mM | 0.0822 mL | 0.4108 mL | 0.8215 mL | 2.0538 mL | |
| 100 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6430 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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