1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. AR7

AR7 

Cat. No.: HY-101106 Purity: 99.70%
Handling Instructions

AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.

For research use only. We do not sell to patients.

AR7 Chemical Structure

AR7 Chemical Structure

CAS No. : 80306-38-3

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Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 432 In-stock
Estimated Time of Arrival: December 31
100 mg USD 780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    AR7 purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284.

    After treated with 1 μM AR7 for 3 days, the protein expression of CD11b, CEBPβ is detected by immunobloting and quantified.
    • Biological Activity

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    • Customer Review

    Description

    AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].

    IC50 & Target

    RARα

     

    In Vitro

    Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2R1441G KI mutant MEFs[1].
    AR7 (10, 20, 30 uM; 12, 24 hours) has no effect on macroautophagy in NIH 3T3 cells[2].
    Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7 significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    257.71

    Formula

    C₁₅H₁₂ClNO

    CAS No.
    SMILES

    CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (97.01 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8803 mL 19.4017 mL 38.8033 mL
    5 mM 0.7761 mL 3.8803 mL 7.7607 mL
    10 mM 0.3880 mL 1.9402 mL 3.8803 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (9.70 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (9.70 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.70 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

    Keywords:

    AR7AR 7AR-7RAR/RXRRetinoic acid receptorsRetinoid X receptorsretinoicacidreceptorCMAmacroautophagyInhibitorinhibitorinhibit

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    Product Name:
    AR7
    Cat. No.:
    HY-101106
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