1. GPCR/G Protein
  2. Bombesin Receptor
  3. Litorin

Litorin 

Cat. No.: HY-103281
Handling Instructions

Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Litorin Chemical Structure

Litorin Chemical Structure

CAS No. : 55749-97-8

Size Price Stock Quantity
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].

In Vitro

99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R)[1].
[D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM[2].
Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1085.24

Formula

C₅₁H₆₈N₁₄O₁₁S

CAS No.
Sequence Shortening

{Pyr}QWAVGHFM

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (92.15 mM; Need ultrasonic)

H2O : 2 mg/mL (1.84 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9215 mL 4.6073 mL 9.2146 mL
5 mM 0.1843 mL 0.9215 mL 1.8429 mL
10 mM 0.0921 mL 0.4607 mL 0.9215 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Litorin
Cat. No.:
HY-103281
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