2'-Hydroxyflavanone
Based on 1 Customer Validation
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC50s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP).
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 17348-76-4
- Formula: C15H12O3
- Molecular Weight:240.25
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Flavonoids Library
HY-L068
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Anti-Cancer Natural Product Library
HY-L107
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Plant-Sourced Natural Product Library
HY-L115
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Coagulation and Anti-coagulation Compound Library
HY-L136
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Cell Death Library
HY-L162
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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RO5 Drug-like Natural Product Library
HY-L200
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Natural Product Diversity Scaffold Library
HY-L245
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Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
4.11 μM
Compound: 1; 2'-HF
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Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
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[PMID: 30189396] |
| J774.A1 | IC50 |
71.3 μM
Compound: 1
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Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
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[PMID: 25824662] |
| J774.A1 | IC50 |
71.3 μM
Compound: 1
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Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
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[PMID: 25824662] |
| J774.A1 | IC50 |
71.3 μM
Compound: 1
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Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
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[PMID: 25824662] |
| LNCaP | IC50 |
5.45 μM
Compound: 1; 2'-HF
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Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
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[PMID: 30189396] |
| PC-3 | IC50 |
2.56 μM
Compound: 1; 2'-HF
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Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
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[PMID: 30189396] |
| RAW264.7 | IC50 |
71.3 μM
Compound: 1
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Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
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[PMID: 25824662] |
| RAW264.7 | IC50 |
71.3 μM
Compound: 1
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
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[PMID: 25824662] |
| RAW264.7 | IC50 |
71.3 μM
Compound: 1
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Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
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[PMID: 25824662] |
Chemical Information
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CAS No. 17348-76-4
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Appearance Solid
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Molecular Weight 240.25
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Formula C15H12O3
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Color White to off-white
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SMILES
O=C1CC(C2=CC=CC=C2O)OC3=CC=CC=C13
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (416.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1623 mL | 20.8117 mL | 41.6233 mL | 104.0583 mL |
| 5 mM | 0.8325 mL | 4.1623 mL | 8.3247 mL | 20.8117 mL | |
| 10 mM | 0.4162 mL | 2.0812 mL | 4.1623 mL | 10.4058 mL | |
| 15 mM | 0.2775 mL | 1.3874 mL | 2.7749 mL | 6.9372 mL | |
| 20 mM | 0.2081 mL | 1.0406 mL | 2.0812 mL | 5.2029 mL | |
| 25 mM | 0.1665 mL | 0.8325 mL | 1.6649 mL | 4.1623 mL | |
| 30 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4686 mL | |
| 40 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6015 mL | |
| 50 mM | 0.0832 mL | 0.4162 mL | 0.8325 mL | 2.0812 mL | |
| 60 mM | 0.0694 mL | 0.3469 mL | 0.6937 mL | 1.7343 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0406 mL |
2'-Hydroxyflavanone Related Classifications
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