2'-Hydroxyflavanone

Cat. No.: HY-134556 Purity: 99.84%: Data Sheet
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2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP).

For research use only. We do not sell to patients.

2'-Hydroxyflavanone Chemical Structure

CAS No. : 17348-76-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	4.11 μM Compound: 1; 2'-HF	Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry	[PMID: 30189396]
J774.A1	IC₅₀	71.3 μM Compound: 1	Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay	[PMID: 25824662]
J774.A1	IC₅₀	71.3 μM Compound: 1	Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay	[PMID: 25824662]
J774.A1	IC₅₀	71.3 μM Compound: 1	Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay	[PMID: 25824662]
LNCaP	IC₅₀	5.45 μM Compound: 1; 2'-HF	Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry	[PMID: 30189396]
PC-3	IC₅₀	2.56 μM Compound: 1; 2'-HF	Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry	[PMID: 30189396]
RAW264.7	IC₅₀	71.3 μM Compound: 1	Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay	[PMID: 25824662]
RAW264.7	IC₅₀	71.3 μM Compound: 1	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay	[PMID: 25824662]
RAW264.7	IC₅₀	71.3 μM Compound: 1	Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay	[PMID: 25824662]

Molecular Weight

240.25

Formula

C₁₅H₁₂O₃

CAS No.

17348-76-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1CC(C2=CC=CC=C2O)OC3=CC=CC=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (416.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1623 mL	20.8117 mL	41.6233 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

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Data Sheet (272 KB) SDS (393 KB)

COA (253 KB) HNMR (247 KB) LCMS (339 KB)

Handling Instructions (2659 KB)

References

[1]. Khaled Alkadi, et al. Antiplatelet aggregation activity of 5-Hydroxyflavone, 2’-Hydroxyflavanone, Paeonol and bergenin isolated from stem bark of Garcinia malaccensis in human whole blood. September 2013Oriental Journal Of Chemistry 29(03):871-875

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1623 mL	20.8117 mL	41.6233 mL	104.0583 mL
	5 mM	0.8325 mL	4.1623 mL	8.3247 mL	20.8117 mL
	10 mM	0.4162 mL	2.0812 mL	4.1623 mL	10.4058 mL
	15 mM	0.2775 mL	1.3874 mL	2.7749 mL	6.9372 mL
	20 mM	0.2081 mL	1.0406 mL	2.0812 mL	5.2029 mL
	25 mM	0.1665 mL	0.8325 mL	1.6649 mL	4.1623 mL
	30 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4686 mL
	40 mM	0.1041 mL	0.5203 mL	1.0406 mL	2.6015 mL
	50 mM	0.0832 mL	0.4162 mL	0.8325 mL	2.0812 mL
	60 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.7343 mL
	80 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL
	100 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0406 mL