2. Cell Cycle/DNA Damage
  3. p97
  4. VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

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VCP/p97 inhibitor-1 Chemical Structure

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

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VCP/p97 inhibitor-1 Related Antibodies

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Description

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
In Vitro

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VCP/p97 inhibitor-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).
Molecular Weight

491.37

Formula

C24H26BN5O4S
CAS No.
SMILES

O=S(NC1=CC=CC2=C1C=C(C)N2C3=NC(CCC4)=C4C(NCC5=CC(B(O)O)=CC=C5)=N3)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VCP/p97 inhibitor-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VCP/p97 inhibitor-12630950-38-6p97VCPCdc48VCP/p97ubiquitin-proteasome systemhomeostasisboronic acidpyrimidineanti-proliferationA549RPMI8226Inhibitorinhibitorinhibit

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