1. Cell Cycle/DNA Damage
  2. p97
  3. VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 

Cat. No.: HY-139606
Handling Instructions

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

For research use only. We do not sell to patients.

VCP/p97 inhibitor-1 Chemical Structure

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

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Description

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1].

IC50 & Target

54.7 nM (VCP/p97) [1]

In Vitro

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).
Molecular Weight

491.37

Formula

C₂₄H₂₆BN₅O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
VCP/p97 inhibitor-1
Cat. No.:
HY-139606
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