1. Cell Cycle/DNA Damage
  2. p97
  3. MSC1094308

MSC1094308 

Cat. No.: HY-123872 Purity: 99.75%
Handling Instructions

MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively.

For research use only. We do not sell to patients.

MSC1094308 Chemical Structure

MSC1094308 Chemical Structure

CAS No. : 2219320-08-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 153 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].

IC50 & Target

IC50: 0.71 μM (VPS4B), 7.2 μM (p97)[1].

Molecular Weight

462.55

Formula

C₂₉H₂₉F₃N₂

CAS No.

2219320-08-6

SMILES

FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1619 mL 10.8096 mL 21.6193 mL
5 mM 0.4324 mL 2.1619 mL 4.3239 mL
10 mM 0.2162 mL 1.0810 mL 2.1619 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.75%

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Keywords:

MSC1094308MSC 1094308MSC-1094308p97VCPCdc48Inhibitorinhibitorinhibit

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MSC1094308
Cat. No.:
HY-123872
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