2630950-38-6
Chemical Structure
VCP/p97 inhibitor-1
- CAS No.: 2630950-38-6
- Formula:C24H26BN5O4S
- Molecular Weight:491.37
IUPAC Name: (3-(((2-(2-methyl-4-(methylsulfonamido)-1H-indol-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)methyl)phenyl)boronic acid
InChIKey: FOBHQTSQEGGBNP-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=CC2=C1C=C(C)N2C3=NC(CCC4)=C4C(NCC5=CC(B(O)O)=CC=C5)=N3)(C)=O
Biological Activity: VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].
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VCP/p97 inhibitor-1 | 98.64% | VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS). | ||||||||||||||||||||
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- [1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114. [Content Brief]
- [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194. [Content Brief]
Keywords
