1. Cell Cycle/DNA Damage
  2. p97

ML240 

Cat. No.: HY-19795 Purity: 99.49%
Data Sheet SDS Handling Instructions

ML240 is a selective, ATP-competitive p97 inhibitor with IC50 values of 100 nM.

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ML240 Chemical Structure

ML240 Chemical Structure

CAS No. : 1346527-98-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $110 In-stock
25 mg $230 In-stock
50 mg $400 In-stock
100 mg $700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

ML240 is a selective, ATP-competitive p97 inhibitor with IC50 values of 100 nM. target : p97[1] IC 50: 100 nM [2] In vitro: ML240 potently stimulated accumulation of LC3-II within minutes, inhibited cancer cell growth, and rapidly mobilized the executioner caspases 3 and 7. The behavior of ML240 suggests that disruption of the protein homeostasis function of p97 leads to more rapid activation of apoptosis than is observed with a proteasome inhibitor. Meanwhile ML240 has broad antiproliferative activity toward the NCI-60 panel of cancer cell lines. [2]

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6122 mL 25.2245 mL
5 mM 0.5045 mL 2.5224 mL 5.0449 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL
References
Molecular Weight

396.44

Formula

C₂₃H₂₀N₆O

CAS No.

1346527-98-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 16.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
ML240
Cat. No.:
HY-19795
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