3FAx-Neu5Ac

Name: 3FAx-Neu5Ac
Brand: MedChemExpress
SKU: HY-110288
Rating: 5.0 (3 reviews)

Cat. No.: HY-110288 Purity: 99.88%: Data Sheet
COA

SDS
Handling Instructions
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3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.

For research use only. We do not sell to patients.

CAS No. : 117405-58-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE 3FAx-Neu5Ac

Flow Cytometry

Bio/Physico-chemical Assay

Cell Imaging/Staining

: 3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: NPJ Breast Cancer. 2026 Jan 24;12(1):29. [Abstract]; Macrophage phagocytosis of 4T1 cells pretreated with PBS control or sialic acid inhibitor 3FAx-Neu5Ac (100 μM; 24 h). 3FAx-Neu5Ac mediated sialic acid removal in 4T1 cells remarkably enhanced macrophage phagocytosis of tumor cells.

: 3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Aug 08.; 3FAX-Neu5Ac (0-200 μM; 24 h) inhibited sialic acid modification in HCT116 cells in a dose-dependent manner.

: 3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.; Fluorescent microscopy of lectin binding in 3FAx-Neu5Ac-treated WT MDBK cells. 3Fax-Neu5Ac (200 μM; 10 d) effectively depleted α2,3/α2,6-linked sialic acids in MDBK cells.

: 3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.; MDBK cells were treated with either DMSO or 3FAx-Neu5Ac (200 μM; 10 d) and subsequently infected with BPIV3 at a MOI of 1. After 24 hours, The levels of viral nucleoprotein (NP) replication within the cells were assessed as a measure of infection.

: 3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.; Primary bovine nasal turbinate cells were isolated and treated with 3Fax-Neu5Ac (200 μM; 10 d) to investigate the distribution of sialic acids. A significant reduction in cell surface sialic acid levels was observed following treatment with the 3Fax-Neu5Ac inhibitor.

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Description

3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X^[1].

In Vitro

3FAx-Neu5Ac (300 μM, 7 days) reduces sialylation on HECA-452 MM1S cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

551.47

Formula

C₂₂H₃₀FNO₁₄

CAS No.

117405-58-0

Appearance

Solid

Color

White to off-white

SMILES

COC([C@]1(O[C@@]([C@H](NC(C)=O)[C@@H](OC(C)=O)[C@H]1F)([H])[C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (181.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8133 mL	9.0667 mL	18.1334 mL
5 mM	0.3627 mL	1.8133 mL	3.6267 mL
10 mM	0.1813 mL	0.9067 mL	1.8133 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (258 KB) HNMR (292 KB) RP-HPLC (241 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Cory D Rillahan, et al. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol. 2012 Jul;8(7):661-8. [Content Brief]

[2]. Natoni A, et al. Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model. Blood, 2018, 132: 3204.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8133 mL	9.0667 mL	18.1334 mL	45.3334 mL
	5 mM	0.3627 mL	1.8133 mL	3.6267 mL	9.0667 mL
	10 mM	0.1813 mL	0.9067 mL	1.8133 mL	4.5333 mL
	15 mM	0.1209 mL	0.6044 mL	1.2089 mL	3.0222 mL
	20 mM	0.0907 mL	0.4533 mL	0.9067 mL	2.2667 mL
	25 mM	0.0725 mL	0.3627 mL	0.7253 mL	1.8133 mL
	30 mM	0.0604 mL	0.3022 mL	0.6044 mL	1.5111 mL
	40 mM	0.0453 mL	0.2267 mL	0.4533 mL	1.1333 mL
	50 mM	0.0363 mL	0.1813 mL	0.3627 mL	0.9067 mL
	60 mM	0.0302 mL	0.1511 mL	0.3022 mL	0.7556 mL
	80 mM	0.0227 mL	0.1133 mL	0.2267 mL	0.5667 mL
	100 mM	0.0181 mL	0.0907 mL	0.1813 mL	0.4533 mL

3FAx-Neu5Ac Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3FAx-Neu5Ac117405-58-0SialyltransferaseSialic acid peracetylated analogsialyltransferase inhibitorLewis XInhibitorinhibitorinhibit

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3FAx-Neu5Ac

Customer Review

3FAx-Neu5Ac Related Antibodies

3 Publications Citing Use of MCE 3FAx-Neu5Ac

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Biological Activity

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3FAx-Neu5Ac Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

3FAx-Neu5Ac Related Classifications

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