NR4A agonist-1
Based on 1 Customer Validation
NR4A agonist-1, a fatty acid mimetic (FAM), is a potent NR4A agonist. NR4A agonist-1 exhibits high agonist potency on NR4A receptors Nurr1, Nur77, and NOR-1, with EC50s of 0.09 μM, 0.04 μM, and 0.15 μM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.75%
- CAS 番号: 360778-55-8
- 分子式: C14H10Cl2O3
- 分子量:297.13
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
NR4A agonist-1 (compound 111) activates full-length human Nurr1 in a more physiological setting on the three response elements NBRE (monomer), NurRE (homodimer), and DR5 (RXR heterodimer) with nanomolar potencies (EC50: 43 nM (NBRE), 22 nM (NurRE), and 21 nM (DR5))[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 360778-55-8
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性状 Solid
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分子量 297.13
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分子式 C14H10Cl2O3
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Color White to off-white
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SMILES
O=C(C1=CC(OCC2=CC=C(C=C2Cl)Cl)=CC=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (420.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3655 mL | 16.8277 mL | 33.6553 mL | 84.1383 mL |
| 5 mM | 0.6731 mL | 3.3655 mL | 6.7311 mL | 16.8277 mL | |
| 10 mM | 0.3366 mL | 1.6828 mL | 3.3655 mL | 8.4138 mL | |
| 15 mM | 0.2244 mL | 1.1218 mL | 2.2437 mL | 5.6092 mL | |
| 20 mM | 0.1683 mL | 0.8414 mL | 1.6828 mL | 4.2069 mL | |
| 25 mM | 0.1346 mL | 0.6731 mL | 1.3462 mL | 3.3655 mL | |
| 30 mM | 0.1122 mL | 0.5609 mL | 1.1218 mL | 2.8046 mL | |
| 40 mM | 0.0841 mL | 0.4207 mL | 0.8414 mL | 2.1035 mL | |
| 50 mM | 0.0673 mL | 0.3366 mL | 0.6731 mL | 1.6828 mL | |
| 60 mM | 0.0561 mL | 0.2805 mL | 0.5609 mL | 1.4023 mL | |
| 80 mM | 0.0421 mL | 0.2103 mL | 0.4207 mL | 1.0517 mL | |
| 100 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8414 mL |
NR4A agonist-1 関連分類
HY-W270810 関連分類
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