NR4A agonist-1
Based on 1 Customer Validation
NR4A agonist-1, a fatty acid mimetic (FAM), is a potent NR4A agonist. NR4A agonist-1 exhibits high agonist potency on NR4A receptors Nurr1, Nur77, and NOR-1, with EC50s of 0.09 μM, 0.04 μM, and 0.15 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 360778-55-8
- Formula: C14H10Cl2O3
- Molecular Weight:297.13
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
NR4A agonist-1 (compound 111) activates full-length human Nurr1 in a more physiological setting on the three response elements NBRE (monomer), NurRE (homodimer), and DR5 (RXR heterodimer) with nanomolar potencies (EC50: 43 nM (NBRE), 22 nM (NurRE), and 21 nM (DR5))[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 360778-55-8
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Appearance Solid
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Molecular Weight 297.13
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Formula C14H10Cl2O3
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Color White to off-white
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SMILES
O=C(C1=CC(OCC2=CC=C(C=C2Cl)Cl)=CC=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (420.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3655 mL | 16.8277 mL | 33.6553 mL | 84.1383 mL |
| 5 mM | 0.6731 mL | 3.3655 mL | 6.7311 mL | 16.8277 mL | |
| 10 mM | 0.3366 mL | 1.6828 mL | 3.3655 mL | 8.4138 mL | |
| 15 mM | 0.2244 mL | 1.1218 mL | 2.2437 mL | 5.6092 mL | |
| 20 mM | 0.1683 mL | 0.8414 mL | 1.6828 mL | 4.2069 mL | |
| 25 mM | 0.1346 mL | 0.6731 mL | 1.3462 mL | 3.3655 mL | |
| 30 mM | 0.1122 mL | 0.5609 mL | 1.1218 mL | 2.8046 mL | |
| 40 mM | 0.0841 mL | 0.4207 mL | 0.8414 mL | 2.1035 mL | |
| 50 mM | 0.0673 mL | 0.3366 mL | 0.6731 mL | 1.6828 mL | |
| 60 mM | 0.0561 mL | 0.2805 mL | 0.5609 mL | 1.4023 mL | |
| 80 mM | 0.0421 mL | 0.2103 mL | 0.4207 mL | 1.0517 mL | |
| 100 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8414 mL |
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