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4-CMTB 

Cat. No.: HY-P1125 Purity: 99.35%
Handling Instructions

4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38).

For research use only. We do not sell to patients.

4-CMTB Chemical Structure

4-CMTB Chemical Structure

CAS No. : 300851-67-6

Size Price Stock Quantity
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].

In Vitro

4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2)[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

294.80

Formula

C₁₄H₁₅ClN₂OS

CAS No.

300851-67-6

SMILES

O=C(NC1=NC=CS1)C(C(C)C)C2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (339.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3921 mL 16.9607 mL 33.9213 mL
5 mM 0.6784 mL 3.3921 mL 6.7843 mL
10 mM 0.3392 mL 1.6961 mL 3.3921 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

4-CMTBOthersligandGPCRsECL2short-chainfreefattyacidsago-allostericInhibitorinhibitorinhibit

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Product Name:
4-CMTB
Cat. No.:
HY-P1125
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